Format

Send to:

Choose Destination

CIDEA cell death-inducing DFFA-like effector a [ Homo sapiens (human) ]

Gene ID: 1149, updated on 3-Sep-2017
Official Symbol
CIDEAprovided by HGNC
Official Full Name
cell death-inducing DFFA-like effector aprovided by HGNC
Primary source
HGNC:HGNC:1976
See related
Ensembl:ENSG00000176194 MIM:604440; Vega:OTTHUMG00000131691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIDE-A
Summary
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Orthologs
Location:
18p11.21; 18
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (12254319..12277595)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12254318..12277594)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC497259 Neighboring gene coiled-coil domain containing 58 pseudogene 3 Neighboring gene uncharacterized LOC105371996 Neighboring gene peptidylprolyl isomerase A pseudogene 56 Neighboring gene RNA, U6 small nuclear 170, pseudogene Neighboring gene tubulin beta 6 class V Neighboring gene AFG3 like matrix AAA peptidase subunit 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Differentiation of white and brown adipocyte, organism-specific biosystem (from WikiPathways)
    Differentiation of white and brown adipocyte, organism-specific biosystemDevelopment of white versus brown adipocytes (figure from Handbook of Obesity). Transcription factors and nuclear regulators controlling the development of white versus brown adipocytes are shown in ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid particle organization TAS
Traceable Author Statement
more info
 
lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequestering of triglyceride ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of apoptotic DNA fragmentation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
cell death activator CIDE-A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001279.3NP_001270.1  cell death activator CIDE-A isoform 1

    See identical proteins and their annotated locations for NP_001270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    BC031896, BQ718688, R73455
    Consensus CDS
    CCDS11856.1
    UniProtKB/Swiss-Prot
    O60543
    UniProtKB/TrEMBL
    Q8N5P9
    Related
    ENSP00000320209.8, OTTHUMP00000162472, ENST00000320477.9, OTTHUMT00000254599
    Conserved Domains (1) summary
    cd06539
    Location:33110
    CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...
  2. NM_001318383.1NP_001305312.1  cell death activator CIDE-A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus than isoform 1.
    Source sequence(s)
    AK122762, AP005264, BC031896
    UniProtKB/TrEMBL
    B3KVA2, Q8N5P9
    Conserved Domains (1) summary
    cd06539
    Location:67144
    CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RNA

  1. NR_134607.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK122762, AP005264, BC031896, BQ718688
    Related
    ENST00000522713.5, OTTHUMT00000381682

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

    Range
    12254319..12277595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    12253696..12277015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center