Format

Send to:

Choose Destination

Chrm4 cholinergic receptor, muscarinic 4 [ Mus musculus (house mouse) ]

Gene ID: 12672, updated on 17-Nov-2020

Summary

Official Symbol
Chrm4provided by MGI
Official Full Name
cholinergic receptor, muscarinic 4provided by MGI
Primary source
MGI:MGI:88399
See related
Ensembl:ENSMUSG00000040495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M4; Chrm-; Chrm-4
Expression
Biased expression in frontal lobe adult (RPKM 11.8), testis adult (RPKM 10.1) and 6 other tissues See more
Orthologs

Genomic context

See Chrm4 in Genome Data Viewer
Location:
2 E1; 2 50.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91752534..91760180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91922189..91929835)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91762346..91769986)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene predicted gene, 39876 Neighboring gene diacylglycerol kinase zeta Neighboring gene midkine Neighboring gene microRNA 6999

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
muscarinic acetylcholine receptor M4
Names
AChR M4
mm4 mAChR
muscarinic acetylcholine receptor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007699.2NP_031725.1  muscarinic acetylcholine receptor M4

    See identical proteins and their annotated locations for NP_031725.1

    Status: VALIDATED

    Source sequence(s)
    AL731772, BC120504, BY250825, BY652985, CX122754, CX241098
    Consensus CDS
    CCDS16439.1
    UniProtKB/Swiss-Prot
    P32211
    UniProtKB/TrEMBL
    Q0VBU3
    Related
    ENSMUSP00000040808.3, ENSMUST00000045537.3
    Conserved Domains (2) summary
    pfam00001
    Location:48453
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40172
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91752534..91760180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498654.3XP_006498717.1  muscarinic acetylcholine receptor M4 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:67472
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:62191
    7tm_4; Olfactory receptor
Support Center