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Chrm4 cholinergic receptor, muscarinic 4 [ Mus musculus (house mouse) ]

Gene ID: 12672, updated on 1-Mar-2024

Summary

Official Symbol
Chrm4provided by MGI
Official Full Name
cholinergic receptor, muscarinic 4provided by MGI
Primary source
MGI:MGI:88399
See related
Ensembl:ENSMUSG00000040495 AllianceGenome:MGI:88399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M4; Chrm-4; AChR M4; mm4 mAChR
Summary
Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway. Located in membrane. Is expressed in several structures, including alimentary system; eye; limb; nervous system; and reproductive system. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 11.8), testis adult (RPKM 10.1) and 6 other tissues See more
Orthologs
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Genomic context

See Chrm4 in Genome Data Viewer
Location:
2 E1; 2 50.63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91752531..91760180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91922189..91929835)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05122 Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene STARR-seq mESC enhancer starr_05123 Neighboring gene predicted gene, 39876 Neighboring gene diacylglycerol kinase zeta Neighboring gene midkine Neighboring gene microRNA 6999

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M4
Names
muscarinic acetylcholine receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416938.1NP_001403867.1  muscarinic acetylcholine receptor M4

    Status: VALIDATED

    Source sequence(s)
    AL731772
    UniProtKB/Swiss-Prot
    P32211, Q64056
    UniProtKB/TrEMBL
    Q0VBU3
  2. NM_007699.3NP_031725.1  muscarinic acetylcholine receptor M4

    See identical proteins and their annotated locations for NP_031725.1

    Status: VALIDATED

    Source sequence(s)
    AL731772
    Consensus CDS
    CCDS16439.1
    UniProtKB/Swiss-Prot
    P32211, Q64056
    UniProtKB/TrEMBL
    Q0VBU3
    Related
    ENSMUSP00000040808.4, ENSMUST00000045537.4
    Conserved Domains (2) summary
    pfam00001
    Location:48453
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40172
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91752531..91760180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)