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CHRM4 cholinergic receptor muscarinic 4 [ Homo sapiens (human) ]

Gene ID: 1132, updated on 3-Dec-2023

Summary

Official Symbol
CHRM4provided by HGNC
Official Full Name
cholinergic receptor muscarinic 4provided by HGNC
Primary source
HGNC:HGNC:1953
See related
Ensembl:ENSG00000180720 MIM:118495; AllianceGenome:HGNC:1953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM4; M4R
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See CHRM4 in Genome Data Viewer
Location:
11p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (46383789..46391776, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46539864..46547851, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46405339..46413326, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46312695-46313398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3301 Neighboring gene cAMP responsive element binding protein 3 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46328063-46328758 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46352624-46352765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46357769-46358498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46360689-46361418 Neighboring gene Sharpr-MPRA regulatory region 11965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3303 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46369312-46369525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46369839-46370824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46373336-46374190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46374191-46375045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46375046-46375899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46377222-46378090 Neighboring gene diacylglycerol kinase zeta Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:46390736-46391935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46401950-46402584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3307 Neighboring gene Sharpr-MPRA regulatory region 2210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46411613-46412218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46412219-46412822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46414340-46415114 Neighboring gene microRNA 4688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46428977-46429764 Neighboring gene midkine Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:46448914-46449505 Neighboring gene ribosomal protein S10 pseudogene 19 Neighboring gene NANOG hESC enhancer GRCh37_chr11:46467611-46468112 Neighboring gene microRNA 3160-1 Neighboring gene microRNA 3160-2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M4
Names
acetylcholine receptor, muscarinic 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000741.5NP_000732.2  muscarinic acetylcholine receptor M4

    See identical proteins and their annotated locations for NP_000732.2

    Status: REVIEWED

    Source sequence(s)
    AC116021
    Consensus CDS
    CCDS44581.1
    UniProtKB/Swiss-Prot
    B2RPP4, P08173, Q0VD60, Q4VBK7
    UniProtKB/TrEMBL
    Q96RG8
    Related
    ENSP00000507561.1, ENST00000682254.1
    Conserved Domains (1) summary
    cd15298
    Location:33464
    7tmA_mAChR_M4; muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001366692.2NP_001353621.1  muscarinic acetylcholine receptor M4

    Status: REVIEWED

    Source sequence(s)
    AC116021
    Consensus CDS
    CCDS44581.1
    UniProtKB/Swiss-Prot
    B2RPP4, P08173, Q0VD60, Q4VBK7
    UniProtKB/TrEMBL
    Q96RG8
    Related
    ENSP00000409378.2, ENST00000433765.3
    Conserved Domains (1) summary
    cd15298
    Location:33464
    7tmA_mAChR_M4; muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    46383789..46391776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    46539864..46547851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)