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CHRM4 cholinergic receptor muscarinic 4 [ Homo sapiens (human) ]

Gene ID: 1132, updated on 2-Oct-2018

Summary

Official Symbol
CHRM4provided by HGNC
Official Full Name
cholinergic receptor muscarinic 4provided by HGNC
Primary source
HGNC:HGNC:1953
See related
Ensembl:ENSG00000180720 MIM:118495; Vega:OTTHUMG00000154371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM4; M4R
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See CHRM4 in Genome Data Viewer
Location:
11p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (46384792..46386608, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46405335..46413122, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase zeta Neighboring gene microRNA 4688 Neighboring gene midkine Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene ribosomal protein S10 pseudogene 19 Neighboring gene microRNA 3160-1 Neighboring gene microRNA 3160-2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M4
Names
acetylcholine receptor, muscarinic 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000741.3NP_000732.2  muscarinic acetylcholine receptor M4

    See identical proteins and their annotated locations for NP_000732.2

    Status: REVIEWED

    Source sequence(s)
    BC137535, BF724332
    Consensus CDS
    CCDS44581.1
    UniProtKB/Swiss-Prot
    P08173
    Related
    ENSP00000409378.2, OTTHUMP00000205575, ENST00000433765.3, OTTHUMT00000334985
    Conserved Domains (1) summary
    cd15298
    Location:33464
    7tmA_mAChR_M4; muscarinic receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    46384792..46386608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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