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RINL Ras and Rab interactor like [ Homo sapiens (human) ]

Gene ID: 126432, updated on 1-Jun-2020

Summary

Official Symbol
RINLprovided by HGNC
Official Full Name
Ras and Rab interactor likeprovided by HGNC
Primary source
HGNC:HGNC:24795
See related
Ensembl:ENSG00000187994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in lymph node (RPKM 5.2), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See RINL in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38867825..38878275, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39358470..39368919, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene sirtuin 2 Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate rich protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44131, FLJ45909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras and Rab interactor-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195833.2NP_001182762.1  ras and Rab interactor-like protein isoform 1

    See identical proteins and their annotated locations for NP_001182762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011455, AK298327
    Consensus CDS
    CCDS59386.1
    UniProtKB/Swiss-Prot
    Q6ZS11
    Related
    ENSP00000467107.1, ENST00000591812.2
    Conserved Domains (2) summary
    pfam02204
    Location:409511
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:40131
    SH2; Src homology 2 (SH2) domain
  2. NM_198445.4NP_940847.1  ras and Rab interactor-like protein isoform 2

    See identical proteins and their annotated locations for NP_940847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC011455, AK298327, DA814564
    Consensus CDS
    CCDS12522.1
    UniProtKB/Swiss-Prot
    Q6ZS11
    Related
    ENSP00000469568.1, ENST00000598904.5
    Conserved Domains (1) summary
    pfam02204
    Location:295397
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38867825..38878275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526455.3XP_011524757.1  ras and Rab interactor-like protein isoform X2

    Conserved Domains (2) summary
    pfam02204
    Location:377479
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:40131
    SH2; Src homology 2 (SH2) domain
  2. XM_006723015.3XP_006723078.1  ras and Rab interactor-like protein isoform X1

    See identical proteins and their annotated locations for XP_006723078.1

    Conserved Domains (2) summary
    pfam02204
    Location:409511
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:40131
    SH2; Src homology 2 (SH2) domain
  3. XM_006723016.3XP_006723079.1  ras and Rab interactor-like protein isoform X3

    Conserved Domains (1) summary
    pfam02204
    Location:295397
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  4. XM_011526454.3XP_011524756.1  ras and Rab interactor-like protein isoform X1

    See identical proteins and their annotated locations for XP_011524756.1

    Conserved Domains (2) summary
    pfam02204
    Location:409511
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:40131
    SH2; Src homology 2 (SH2) domain
  5. XM_024451363.1XP_024307131.1  ras and Rab interactor-like protein isoform X3

    Conserved Domains (1) summary
    pfam02204
    Location:295397
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    277502..287947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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