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CYP4F22 cytochrome P450 family 4 subfamily F member 22 [ Homo sapiens (human) ]

Gene ID: 126410, updated on 18-Aug-2020

Summary

Official Symbol
CYP4F22provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 22provided by HGNC
Primary source
HGNC:HGNC:26820
See related
Ensembl:ENSG00000171954 MIM:611495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LI3; ARCI5; INLNE
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 11.5), esophagus (RPKM 6.1) and 3 other tissues See more
Orthologs

Genomic context

See CYP4F22 in Genome Data Viewer
Location:
19p13.12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15508487..15552317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15619336..15663128)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAS protein activator like 3 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ribosomal protein L23a pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39501

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
icosanoid metabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 4F22
Names
cytochrome P450, family 2, subfamily E, polypeptide 2 homolog
cytochrome P450, family 4, subfamily F, polypeptide 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007987.1 RefSeqGene

    Range
    5001..48793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173483.4NP_775754.2  cytochrome P450 4F22

    See identical proteins and their annotated locations for NP_775754.2

    Status: REVIEWED

    Source sequence(s)
    AC011492, AI341068, BC069351, DA874258
    Consensus CDS
    CCDS12331.1
    UniProtKB/Swiss-Prot
    Q6NT55
    Related
    ENSP00000269703.1, ENST00000269703.8
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15508487..15552317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527692.2XP_011525994.1  cytochrome P450 4F22 isoform X1

    See identical proteins and their annotated locations for XP_011525994.1

    UniProtKB/Swiss-Prot
    Q6NT55
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450
  2. XM_011527693.2XP_011525995.1  cytochrome P450 4F22 isoform X1

    See identical proteins and their annotated locations for XP_011525995.1

    UniProtKB/Swiss-Prot
    Q6NT55
    Conserved Domains (1) summary
    pfam00067
    Location:60524
    p450; Cytochrome P450
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