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Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 12614, updated on 28-Feb-2023

Summary

Official Symbol
Celsr1provided by MGI
Official Full Name
cadherin, EGF LAG seven-pass G-type receptor 1provided by MGI
Primary source
MGI:MGI:1100883
See related
Ensembl:ENSMUSG00000016028 AllianceGenome:MGI:1100883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scy; Crsh; crash; Adgrc1
Summary
Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including Rho protein signal transduction; apical protein localization; and morphogenesis of an epithelium. Located in membrane. Is expressed in several structures, including blastocyst; central nervous system; epithelium; primitive streak; and renal cortex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 9.9), ovary adult (RPKM 9.8) and 18 other tissues See more
Orthologs
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Genomic context

See Celsr1 in Genome Data Viewer
Location:
15 E2; 15 40.42 cM
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85782959..85918424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85898758..86034223, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene G two S phase expressed protein 1 Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase Neighboring gene predicted gene, 34764 Neighboring gene predicted gene, 41375 Neighboring gene GRAM domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within establishment of body hair planar orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization involved in establishment of planar polarity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin EGF LAG seven-pass G-type receptor 1
Names
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
seven-pass transmembrane receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009886.2NP_034016.2  cadherin EGF LAG seven-pass G-type receptor 1 precursor

    See identical proteins and their annotated locations for NP_034016.2

    Status: VALIDATED

    Source sequence(s)
    AC116764, AC139513, AF031572, BQ180311, BQ942572, CV561900
    Consensus CDS
    CCDS37172.1
    UniProtKB/Swiss-Prot
    E9QK27, O35161
    Related
    ENSMUSP00000016172.8, ENSMUST00000016172.10
    Conserved Domains (10) summary
    smart00303
    Location:24222475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:20672128
    HormR; Domain present in hormone receptors
    cd00054
    Location:18891923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20172055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:24812712
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02210
    Location:17341864
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:21462394
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:19302026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85782959..85918424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248310.1XP_030104170.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

    Conserved Domains (11) summary
    smart00303
    Location:24222475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:20672128
    HormR; Domain present in hormone receptors
    cd00054
    Location:18891923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20172055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:19512000
    TNFRSF; CRD3 [structural motif]
    cd15991
    Location:24802733
    7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02210
    Location:17341861
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:21452396
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:19302026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. XM_006520380.2XP_006520443.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

    Conserved Domains (11) summary
    smart00303
    Location:24222475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:20672128
    HormR; Domain present in hormone receptors
    cd00054
    Location:18891923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20172055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:19512000
    TNFRSF; CRD3 [structural motif]
    cd15991
    Location:24802733
    7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02210
    Location:17341861
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:21452396
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:19302026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. XM_006520379.2XP_006520442.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

    Conserved Domains (11) summary
    smart00303
    Location:24222475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:20672128
    HormR; Domain present in hormone receptors
    cd00054
    Location:18891923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20172055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:19512000
    TNFRSF; CRD3 [structural motif]
    cd15991
    Location:24802733
    7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02210
    Location:17341861
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:21452396
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:19302026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  4. XM_006520381.3XP_006520444.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X4

    Conserved Domains (11) summary
    smart00303
    Location:24222475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:20672128
    HormR; Domain present in hormone receptors
    cd00054
    Location:18891923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20172055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:19512000
    TNFRSF; CRD3 [structural motif]
    cd15991
    Location:24802733
    7tmB2_CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02210
    Location:17341861
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:21452396
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:19302026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  5. XM_006520382.4XP_006520445.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X5

    Related
    ENSMUSP00000153927.2, ENSMUST00000226840.2
    Conserved Domains (10) summary
    smart00303
    Location:12061259
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:851912
    HormR; Domain present in hormone receptors
    smart00179
    Location:206240
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:673707
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:801839
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:243426
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd14964
    Location:12661291
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam02210
    Location:518645
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:9291180
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:12641517
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_036159109.1XP_036015002.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X6

    Conserved Domains (3) summary
    cd11304
    Location:808903
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:13791414
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:14591642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...