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Cebpg CCAAT/enhancer binding protein gamma [ Mus musculus (house mouse) ]

Gene ID: 12611, updated on 21-Apr-2024

Summary

Official Symbol
Cebpgprovided by MGI
Official Full Name
CCAAT/enhancer binding protein gammaprovided by MGI
Primary source
MGI:MGI:104982
See related
Ensembl:ENSMUSG00000056216 AllianceGenome:MGI:104982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpe1bp; Ig/EBP; GPE1-BP; C/EBP[g]; C/EBPgamma
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in enucleate erythrocyte differentiation; natural killer cell mediated cytotoxicity; and regulation of gene expression. Acts upstream of or within B cell differentiation and mRNA metabolic process. Located in nucleus. Is expressed in several structures, including blood; central nervous system; genitourinary system; retina; and yolk sac. Orthologous to human CEBPG (CCAAT enhancer binding protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 10.2), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 B2; 7 20.91 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34745847..34755991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35046422..35056566, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene peptidase D Neighboring gene predicted gene, 25922 Neighboring gene STARR-seq mESC enhancer starr_18614 Neighboring gene predicted gene, 35534 Neighboring gene STARR-positive B cell enhancer ABC_E6536 Neighboring gene predicted gene 45095 Neighboring gene STARR-seq mESC enhancer starr_18615 Neighboring gene predicted gene, 35611 Neighboring gene CCAAT/enhancer binding protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
NOT enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
involved_in enucleate erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome disassembly TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein gamma
Names
CCAAT/enhancer binding protein (C/EBP), gamma
G-CSF promoter element 1 binding protein
GPE1-BP (C/EBP gamma)
GPE1-binding protein
IG/EBP-1
c/EBP gamma
granulocyte colony-stimulating factor promoter element 1-binding protein
immunoglobulin enhancer-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009884.3NP_034014.1  CCAAT/enhancer-binding protein gamma

    See identical proteins and their annotated locations for NP_034014.1

    Status: VALIDATED

    Source sequence(s)
    AC149058, AK159544, BE987706, CJ092456
    Consensus CDS
    CCDS21144.1
    UniProtKB/Swiss-Prot
    P53568
    UniProtKB/TrEMBL
    Q54AJ1
    Related
    ENSMUSP00000118588.2, ENSMUST00000130491.3
    Conserved Domains (1) summary
    cd14713
    Location:60120
    bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    34745847..34755991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)