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CEBPG CCAAT enhancer binding protein gamma [ Homo sapiens (human) ]

Gene ID: 1054, updated on 1-Jun-2020

Summary

Official Symbol
CEBPGprovided by HGNC
Official Full Name
CCAAT enhancer binding protein gammaprovided by HGNC
Primary source
HGNC:HGNC:1837
See related
Ensembl:ENSG00000153879 MIM:138972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPE1BP; IG/EBP-1
Summary
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in thyroid (RPKM 20.4), colon (RPKM 19.6) and 25 other tissues See more
Orthologs

Genomic context

See CEBPG in Genome Data Viewer
Location:
19q13.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (33373709..33382686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33864575..33873592)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 50 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 7 Neighboring gene peptidase D Neighboring gene uncharacterized LOC105372370

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection increases basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5 PubMed
Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
enucleate erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
liver development ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of DNA binding TAS
Traceable Author Statement
more info
PubMed 
positive regulation of DNA repair IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein gamma
Names
CCAAT/enhancer binding protein (C/EBP), gamma
c/EBP gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252296.1NP_001239225.1  CCAAT/enhancer-binding protein gamma

    See identical proteins and their annotated locations for NP_001239225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008744, BC013128, CN353219
    Consensus CDS
    CCDS12432.1
    UniProtKB/Swiss-Prot
    P53567
    Related
    ENSP00000466022.2, ENST00000585933.2
    Conserved Domains (1) summary
    cd14713
    Location:60120
    bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain
  2. NM_001806.4NP_001797.1  CCAAT/enhancer-binding protein gamma

    See identical proteins and their annotated locations for NP_001797.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008744, BC007582, BC013128
    Consensus CDS
    CCDS12432.1
    UniProtKB/Swiss-Prot
    P53567
    Related
    ENSP00000284000.2, ENST00000284000.9
    Conserved Domains (1) summary
    cd14713
    Location:60120
    bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    33373709..33382686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451327.1XP_024307095.1  CCAAT/enhancer-binding protein gamma isoform X1

    Conserved Domains (1) summary
    cd14713
    Location:60120
    bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain
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