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Cd63 CD63 antigen [ Mus musculus (house mouse) ]

Gene ID: 12512, updated on 12-May-2024

Summary

Official Symbol
Cd63provided by MGI
Official Full Name
CD63 antigenprovided by MGI
Primary source
MGI:MGI:99529
See related
Ensembl:ENSMUSG00000025351 AllianceGenome:MGI:99529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ME491; Tspan30
Summary
Involved in pigment cell differentiation and regulation of vascular endothelial growth factor signaling pathway. Located in late endosome and lysosome. Is expressed in blood vessel; brain; eye anterior segment; and intestine. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 201.9), placenta adult (RPKM 183.2) and 25 other tissues See more
Orthologs
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Genomic context

See Cd63 in Genome Data Viewer
Location:
10 D3; 10 77.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128731577..128748691)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128896231..128912822)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E10662 Neighboring gene growth differentiation factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene integrin alpha 7 Neighboring gene predicted gene, 25494

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103180, MGC107286

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to melanosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in pigment cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pigment granule maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body, internal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CD63 antigen
Names
melanoma 1 antigen

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042580.2NP_001036045.1  CD63 antigen

    See identical proteins and their annotated locations for NP_001036045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24297.1
    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Related
    ENSMUSP00000100862.2, ENSMUST00000105229.9
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family
  2. NM_001282966.2NP_001269895.1  CD63 antigen

    See identical proteins and their annotated locations for NP_001269895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24297.1
    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family
  3. NM_001428408.1NP_001415337.1  CD63 antigen

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC122380
    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q549D0
  4. NM_001428409.1NP_001415338.1  CD63 antigen

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC122380
    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q549D0
  5. NM_007653.4NP_031679.1  CD63 antigen

    See identical proteins and their annotated locations for NP_031679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24297.1
    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Related
    ENSMUSP00000026407.8, ENSMUST00000026407.9
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128731577..128748691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155570.1XP_036011463.1  CD63 antigen isoform X1

    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family
  2. XM_030244852.1XP_030100712.1  CD63 antigen isoform X1

    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family
  3. XM_030244851.1XP_030100711.1  CD63 antigen isoform X1

    UniProtKB/Swiss-Prot
    P41731
    UniProtKB/TrEMBL
    Q3UC80, Q549D0
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:10227
    Tetraspannin; Tetraspanin family