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CD63 CD63 molecule [ Homo sapiens (human) ]

Gene ID: 967, updated on 3-Jun-2018
Official Symbol
CD63provided by HGNC
Official Full Name
CD63 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1692
See related
Ensembl:ENSG00000135404 MIM:155740; Vega:OTTHUMG00000170454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues See more
Orthologs
See CD63 in Genome Data Viewer
Location:
12q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (55725443..55729673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56119227..56123457, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 7 Neighboring gene BLOC1S1-RDH5 readthrough Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 1 Neighboring gene uncharacterized LOC105369779 Neighboring gene retinol dehydrogenase 5 Neighboring gene growth differentiation factor 11 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene ORMDL sphingolipid biosynthesis regulator 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 LAI replication requires CD63 expression as knockdown with shRNA decreases viral production in HeLa cells PubMed
siRNA knockdown of CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) decreases CA (p24) levels in supernatants but does not affect intracellular CA (p24) levels PubMed
siRNA knockdown of CD63 decreases CCR5-tropic (ADA) and dual-tropic (89.6) pseudotyped virus (luciferase reporter HIV backbone presumed) infection of MDMs, yet does not affect MLV- and VSV-pseudotyped virus infection, as measured by luciferase activity PubMed
siRNA knockdown of CD63 decreases HIV production from peripheral blood lymphocytes and dendritic cells as measured by supernatant CA (p24) levels PubMed
siRNA knockdown of CD63 decreases HIV production from monocyte-derived macrophages (MDMs) infected with HIV-1 (SX strain) at a low multiplicity of infection (MOI= 0.02) PubMed
Knockdown of CD63 by siRNA inhibits HIV-1 infection and replication in human CD4+ T cells, macrophages, and peripheral blood lymphocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CD63 enhances HIV-1 gp120/gp41-mediated entry in human macrophages PubMed
env HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation PubMed
env Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63 PubMed
env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env co-localizes with CD63 in HIV-1 infected CD4+ T cells PubMed
env Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63 PubMed
env DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures PubMed
env In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding PubMed
env CD63 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 co-localizes predominantly with CD63 at the virological synapse of Jurkat cells PubMed
env CD63 enhances HIV-1 gp120/gp41-mediated entry in human macrophages PubMed
env Recruitment of Env to tetraspanin-enriched microdomains (TEMs) is required for cell-cell fusion repression by CD9 and CD63 PubMed
env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
Nef nef HIV-1 Nef induces release of CD63 (MAL-dependent exosome marker) from Jurkat T cells transfected with DNA constructs coding for Nef-GFP PubMed
nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD63 (TSPAN30) PubMed
nef HIV-1 Nef targets CD4 to CD63-containing lysosomes for Nef-induced degradation of CD4, which requires the VPS4-mediated ESCRT machinery PubMed
nef HIV-1 Nef increases the production of exosomes, which form in the late endosomes and co-localizes with the late endosomal marker CD63 in SupT cells PubMed
nef HIV-1 Nef increases the production of exosomes, co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Co-localization of HIV-1 Gag virus-like particles in THP-1/CD169YF cells is reduced within CD81+ compartments, but enhanced within CD63+ or LAMP1+ compartments PubMed
gag HIV-1 Gag proteins co-localize with CD63 and CD81 in intracellular exosomes PubMed
gag HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation PubMed
gag Tetherin co-localizes with HIV-1 Gag in CD81- and CD63-enriched intracellular virus-containing compartments in macrophages, and that a separate population of tetherin is located in the TGN PubMed
gag The budding defect of p6-deficient HIV-1 Gag is caused primarily by C-terminal exposure of p1. The p1 domain of p6-deficient Gag acts as an inhibitory budding signal by blocking the interaction of Gag with CD63 and VPS4B PubMed
gag Env-mediated cell-cell fusion repression by CD9 and CD63 requires the presence of HIV-1 Gag PubMed
gag DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures PubMed
gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains PubMed
gag A dileucine-like motif (residues 321-322) in HIV-1 Gag regulates the assembly of Gag into CD63-positive multivesicular bodies PubMed
gag In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
Tat tat siRNA-mediated CD63 down regulation reduces production of the early HIV protein Tat in both macrophages and a CD4(+) cell line PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD63 (TSPAN30) PubMed
capsid gag HIV-1 Gag colocalizes with CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) PubMed
gag siRNA knockdown of CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) affects CA (p24) levels in supernatants (decreases) but not intracellular CA (p24) levels PubMed
gag HIV-1 Gag, CA, and gp120 proteins co-localizes with CD63 and acetylcholinesterase (ACHE)-associated exosomes from supernatants of HIV-1 expressing cells. The 5' end of the Gag p17 open reading frame is sufficient for HIV-1 RNA exosome incorporation PubMed
gag CD63 silencing inhibits production of the late protein CA p24 in early HIV-1 replication events in both macrophages and a CD4(+) cell line PubMed
gag In human macrophages, HIV-1 Capsid (p24) co-localizes with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
matrix gag HIV-1 Gag colocalizes with CD63 in U1/HIV-1 cells (chronically infected monocytoid cells harboring 2 integrated copies of HIV provirus per cell) PubMed
gag In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding PubMed

Go to the HIV-1, Human Interaction Database

  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
endosome to melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
pigment granule maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endosome lumen IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane HDA PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
multivesicular body membrane HDA PubMed 
multivesicular body membrane IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body, internal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet dense granule membrane TAS
Traceable Author Statement
more info
 
Preferred Names
CD63 antigen
Names
CD63 antigen (melanoma 1 antigen)
granulophysin
lysosomal-associated membrane protein 3
lysosome-associated membrane glycoprotein 3
melanoma-associated antigen ME491
melanoma-associated antigen MLA1
ocular melanoma-associated antigen
tetraspanin-30
tspan-30

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008347.1 RefSeqGene

    Range
    4989..8684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257389.1NP_001244318.1  CD63 antigen isoform A

    See identical proteins and their annotated locations for NP_001244318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3, 4, 5 and 10 encode the same isoform A.
    Source sequence(s)
    BU960599, CB128206, CD250685, CN296813
    Consensus CDS
    CCDS8890.1
    UniProtKB/Swiss-Prot
    P08962
    UniProtKB/TrEMBL
    A0A024RB05
    Related
    ENSP00000447730.1, OTTHUMP00000243855, ENST00000549117.5, OTTHUMT00000409234
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
  2. NM_001257390.1NP_001244319.1  CD63 antigen isoform A

    See identical proteins and their annotated locations for NP_001244319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3, 4, 5 and 10 encode the same isoform A.
    Source sequence(s)
    BG478842, BU960599
    Consensus CDS
    CCDS8890.1
    UniProtKB/Swiss-Prot
    P08962
    UniProtKB/TrEMBL
    A0A024RB05
    Related
    ENSP00000393502.3, ENST00000420846.7
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
  3. NM_001257391.1NP_001244320.1  CD63 antigen isoform A

    See identical proteins and their annotated locations for NP_001244320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR segment, compared to variant 1. Variants 1, 3, 4, 5 and 10 encode the same isoform A.
    Source sequence(s)
    AL582859, BE407235, BU960599
    Consensus CDS
    CCDS8890.1
    UniProtKB/Swiss-Prot
    P08962
    UniProtKB/TrEMBL
    A0A024RB05
    Related
    ENSP00000449337.1, OTTHUMP00000243854, ENST00000552692.5, OTTHUMT00000409233
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
  4. NM_001257392.1NP_001244321.1  CD63 antigen isoform C

    See identical proteins and their annotated locations for NP_001244321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (C) lacks an internal segment, compared to isoform A.
    Source sequence(s)
    AF508304, BU960599, CN484590
    Consensus CDS
    CCDS58243.1
    UniProtKB/Swiss-Prot
    P08962
    Related
    ENSP00000446807.1, OTTHUMP00000243857, ENST00000552754.5, OTTHUMT00000409236
    Conserved Domains (2) summary
    cd03166
    Location:82180
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:28208
    Tetraspannin; Tetraspanin family
  5. NM_001257400.1NP_001244329.1  CD63 antigen isoform D precursor

    See identical proteins and their annotated locations for NP_001244329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8 and 9 encode the same isoform D.
    Source sequence(s)
    BC013017, BG766593, BU960599
    Consensus CDS
    CCDS58242.1
    UniProtKB/Swiss-Prot
    P08962
    Related
    ENSP00000447356.1, OTTHUMP00000243853, ENST00000546939.5, OTTHUMT00000409232
    Conserved Domains (2) summary
    cd03166
    Location:23121
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:1149
    Tetraspannin; Tetraspanin family
  6. NM_001257401.1NP_001244330.1  CD63 antigen isoform D precursor

    See identical proteins and their annotated locations for NP_001244330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8 and 9 encode the same isoform D.
    Source sequence(s)
    BQ434569, BU190521, BU960599
    Consensus CDS
    CCDS58242.1
    UniProtKB/Swiss-Prot
    P08962
    Related
    ENSP00000448091.1, OTTHUMP00000243970, ENST00000550776.5, OTTHUMT00000409489
    Conserved Domains (2) summary
    cd03166
    Location:23121
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:1149
    Tetraspannin; Tetraspanin family
  7. NM_001267698.1NP_001254627.1  CD63 antigen isoform A

    See identical proteins and their annotated locations for NP_001254627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3, 4, 5 and 10 encode the same isoform A.
    Source sequence(s)
    AA583189, BC002349, BU167765
    Consensus CDS
    CCDS8890.1
    UniProtKB/Swiss-Prot
    P08962
    UniProtKB/TrEMBL
    A0A024RB05
    Related
    ENSP00000449281.1, OTTHUMP00000243858, ENST00000552164.5, OTTHUMT00000409237
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
  8. NM_001780.5NP_001771.1  CD63 antigen isoform A

    See identical proteins and their annotated locations for NP_001771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A). Variants 1, 3, 4, 5 and 10 encode the same isoform A.
    Source sequence(s)
    BU960599, DB495090, EB386351
    Consensus CDS
    CCDS8890.1
    UniProtKB/Swiss-Prot
    P08962
    UniProtKB/TrEMBL
    A0A024RB05
    Related
    ENSP00000257857.4, OTTHUMP00000243856, ENST00000257857.8, OTTHUMT00000409235
    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    55725443..55729673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449283.1XP_024305051.1  CD63 antigen isoform X1

    Conserved Domains (2) summary
    cd03166
    Location:105203
    CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam15807
    Location:3370
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040034.1: Suppressed sequence

    Description
    NM_001040034.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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