U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd37 CD37 antigen [ Mus musculus (house mouse) ]

Gene ID: 12493, updated on 18-Apr-2024

Summary

Official Symbol
Cd37provided by MGI
Official Full Name
CD37 antigenprovided by MGI
Primary source
MGI:MGI:88330
See related
Ensembl:ENSMUSG00000030798 AllianceGenome:MGI:88330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tspan26
Summary
Acts upstream of or within several processes, including defense response to protozoan; negative regulation of myeloid dendritic cell activation; and positive regulation of immunoglobulin production. Predicted to be located in immunological synapse. Predicted to be integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human CD37 (CD37 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 338.0), mammary gland adult (RPKM 92.9) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
7 B3; 7 29.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44883056..44888701, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45233632..45239340, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dickkopf-like 1 Neighboring gene TEA domain family member 2 Neighboring gene STARR-seq mESC enhancer starr_18834 Neighboring gene STARR-positive B cell enhancer ABC_E872 Neighboring gene STARR-seq mESC enhancer starr_18835 Neighboring gene solute carrier family 6, member 16 Neighboring gene predicted gene, 23585 Neighboring gene solute carrier family 6 member 21

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290802.1NP_001277731.1  leukocyte antigen CD37 isoform 1

    See identical proteins and their annotated locations for NP_001277731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC150897, BY548149, CT010217, CX226822
    Consensus CDS
    CCDS71958.1
    UniProtKB/TrEMBL
    A0A1B0GSZ7, Q3U429
    Related
    ENSMUSP00000033063.7, ENSMUST00000033063.15
    Conserved Domains (2) summary
    cd03160
    Location:130265
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:48292
    Tetraspannin; Tetraspanin family
  2. NM_001290804.1NP_001277733.1  leukocyte antigen CD37 isoform 2

    See identical proteins and their annotated locations for NP_001277733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.
    Source sequence(s)
    AC150897, BE849269, BY548149, CT010217, CX226822
    UniProtKB/TrEMBL
    A0A1B0GS72
    Related
    ENSMUSP00000147818.2, ENSMUST00000210078.2
    Conserved Domains (3) summary
    cd03160
    Location:105240
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:21267
    Tetraspannin; Tetraspanin family
    pfam13908
    Location:144
    Shisa; Wnt and FGF inhibitory regulator
  3. NM_007645.4NP_031671.1  leukocyte antigen CD37 isoform 3

    See identical proteins and their annotated locations for NP_031671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC150897
    Consensus CDS
    CCDS21237.1
    UniProtKB/Swiss-Prot
    Q61470
    UniProtKB/TrEMBL
    A0A1B0GSZ7, Q4FK35
    Related
    ENSMUSP00000096061.2, ENSMUST00000098461.10
    Conserved Domains (2) summary
    cd03160
    Location:108243
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:26270
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44883056..44888701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540593.5XP_006540656.1  leukocyte antigen CD37 isoform X2

    Conserved Domains (1) summary
    cd03160
    Location:105240
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. XM_006540592.5XP_006540655.1  leukocyte antigen CD37 isoform X1

    Conserved Domains (1) summary
    cd03160
    Location:130265
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...