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CD37 CD37 molecule [ Homo sapiens (human) ]

Gene ID: 951, updated on 13-Feb-2019

Summary

Official Symbol
CD37provided by HGNC
Official Full Name
CD37 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1666
See related
Ensembl:ENSG00000104894 MIM:151523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP52-40; TSPAN26
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues See more
Orthologs

Genomic context

See CD37 in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49334961..49340608)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49838632..49843863)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene microRNA 4324 Neighboring gene TEA domain transcription factor 2 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene coiled-coil domain containing 155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD37 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Nef PubMed
nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed
Vpu vpu Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Vpu PubMed
vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...

General gene information

Markers

Homology

Clone Names

  • MGC120234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
leukocyte antigen CD37
Names
cell differentiation antigen 37
leukocyte surface antigen CD37
tetraspanin-26
tspan-26

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033941.1 RefSeqGene

    Range
    5001..10187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040031.1NP_001035120.1  leukocyte antigen CD37 isoform B

    See identical proteins and their annotated locations for NP_001035120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (B) has a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    AA767248, AC010524, AC011450
    Consensus CDS
    CCDS46139.1
    UniProtKB/Swiss-Prot
    P11049
    Related
    ENSP00000413151.1, ENST00000426897.6
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1202
    Tetraspannin; Tetraspanin family
  2. NM_001774.3NP_001765.1  leukocyte antigen CD37 isoform A

    See identical proteins and their annotated locations for NP_001765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AA767248, AC010524, AC011450, BP309557
    Consensus CDS
    CCDS12760.1
    UniProtKB/Swiss-Prot
    P11049
    Related
    ENSP00000325708.3, ENST00000323906.8
    Conserved Domains (2) summary
    cd03160
    Location:108243
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:26270
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    49334961..49340608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527543.3XP_011525845.1  leukocyte antigen CD37 isoform X2

    See identical proteins and their annotated locations for XP_011525845.1

    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1201
    Tetraspannin; Tetraspanin family
  2. XM_011527544.3XP_011525846.1  leukocyte antigen CD37 isoform X3

    See identical proteins and their annotated locations for XP_011525846.1

    UniProtKB/Swiss-Prot
    P11049
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1202
    Tetraspannin; Tetraspanin family
  3. XM_011527542.3XP_011525844.1  leukocyte antigen CD37 isoform X2

    See identical proteins and their annotated locations for XP_011525844.1

    Related
    ENSP00000470683.1, ENST00000594743.1
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1201
    Tetraspannin; Tetraspanin family
  4. XM_005259435.3XP_005259492.1  leukocyte antigen CD37 isoform X1

    Conserved Domains (2) summary
    cd03160
    Location:108243
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:26269
    Tetraspannin; Tetraspanin family
  5. XM_005259436.3XP_005259493.1  leukocyte antigen CD37 isoform X2

    See identical proteins and their annotated locations for XP_005259493.1

    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1201
    Tetraspannin; Tetraspanin family
  6. XM_017027513.1XP_016883002.1  leukocyte antigen CD37 isoform X3

    UniProtKB/Swiss-Prot
    P11049
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1202
    Tetraspannin; Tetraspanin family
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