U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD37 CD37 molecule [ Homo sapiens (human) ]

Gene ID: 951, updated on 10-Oct-2023

Summary

Official Symbol
CD37provided by HGNC
Official Full Name
CD37 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1666
See related
Ensembl:ENSG00000104894 MIM:151523; AllianceGenome:HGNC:1666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP52-40; TSPAN26
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CD37 in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49335406..49340606)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52332834..52338034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49838663..49843863)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49816848-49817070 Neighboring gene microRNA 4324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14931 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49830555-49830706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49842721-49843696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14936 Neighboring gene TEA domain transcription factor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49863002-49863502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49864048-49864757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49864758-49865466 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene KASH domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14937 Neighboring gene uncharacterized LOC124904740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918083-49918637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918638-49919191

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD37 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Nef PubMed
nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed
Vpu vpu Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Vpu PubMed
vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
leukocyte antigen CD37
Names
cell differentiation antigen 37
leukocyte surface antigen CD37
tetraspanin-26
tspan-26

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033941.1 RefSeqGene

    Range
    4987..10187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040031.2NP_001035120.1  leukocyte antigen CD37 isoform B

    See identical proteins and their annotated locations for NP_001035120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (B) has a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    AA767248, AC010524, AC011450
    Consensus CDS
    CCDS46139.1
    UniProtKB/Swiss-Prot
    P11049
    Related
    ENSP00000413151.1, ENST00000426897.6
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1202
    Tetraspannin; Tetraspanin family
  2. NM_001774.3NP_001765.1  leukocyte antigen CD37 isoform A

    See identical proteins and their annotated locations for NP_001765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AA767248, AC010524, AC011450, BP309557
    Consensus CDS
    CCDS12760.1
    UniProtKB/Swiss-Prot
    B4DVC1, P11049, Q3KPF9
    UniProtKB/TrEMBL
    B7ZAN3
    Related
    ENSP00000325708.3, ENST00000323906.9
    Conserved Domains (2) summary
    cd03160
    Location:108243
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:26270
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49335406..49340606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259435.4XP_005259492.1  leukocyte antigen CD37 isoform X1

    Conserved Domains (2) summary
    cd03160
    Location:108243
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:26269
    Tetraspannin; Tetraspanin family
  2. XM_011527542.4XP_011525844.1  leukocyte antigen CD37 isoform X2

    See identical proteins and their annotated locations for XP_011525844.1

    UniProtKB/TrEMBL
    M0QZP6
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1201
    Tetraspannin; Tetraspanin family
  3. XM_011527543.4XP_011525845.1  leukocyte antigen CD37 isoform X2

    See identical proteins and their annotated locations for XP_011525845.1

    UniProtKB/TrEMBL
    M0QZP6
    Related
    ENSP00000470683.1, ENST00000594743.1
    Conserved Domains (2) summary
    cd03160
    Location:40175
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1201
    Tetraspannin; Tetraspanin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52332834..52338034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322710.1XP_054178685.1  leukocyte antigen CD37 isoform X1

  2. XM_054322711.1XP_054178686.1  leukocyte antigen CD37 isoform X2

    UniProtKB/TrEMBL
    M0QZP6
  3. XM_054322714.1XP_054178689.1  leukocyte antigen CD37 isoform X3

  4. XM_054322712.1XP_054178687.1  leukocyte antigen CD37 isoform X2

    UniProtKB/TrEMBL
    M0QZP6
  5. XM_054322713.1XP_054178688.1  leukocyte antigen CD37 isoform X2

    UniProtKB/TrEMBL
    M0QZP6