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Cd34 CD34 antigen [ Mus musculus (house mouse) ]

Gene ID: 12490, updated on 25-Jan-2022

Summary

Official Symbol
Cd34provided by MGI
Official Full Name
CD34 antigenprovided by MGI
Primary source
MGI:MGI:88329
See related
Ensembl:ENSMUSG00000016494 AllianceGenome:MGI:88329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU040960
Summary
Enables sulfate binding activity. Acts upstream of or within leukocyte migration. Located in cytoplasm; external side of plasma membrane; and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; genitourinary system; and skin. Orthologous to human CD34 (CD34 molecule). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in bladder adult (RPKM 83.8), subcutaneous fat pad adult (RPKM 60.4) and 21 other tissues See more
Orthologs
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Genomic context

See Cd34 in Genome Data Viewer
Location:
1 H6; 1 98.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194621129..194643600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (194938821..194961292)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (196765015..196787486)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microRNA 3962 Neighboring gene predicted gene, 39748 Neighboring gene predicted gene, 16897 Neighboring gene predicted gene, 53516 Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in paracrine signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell-derived neurotrophic factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
part_of glomerular endothelium fenestra ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hematopoietic progenitor cell antigen CD34
Names
cluster designation 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111059.1NP_001104529.1  hematopoietic progenitor cell antigen CD34 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter protein (isoform 1).
    Source sequence(s)
    AK044121, AV319386, BY249301, BY327943
    Consensus CDS
    CCDS48490.1
    UniProtKB/TrEMBL
    Q543Y2
    Related
    ENSMUSP00000106439.3, ENSMUST00000110815.9
    Conserved Domains (1) summary
    pfam06365
    Location:187325
    CD34_antigen; CD34/Podocalyxin family
  2. NM_133654.3NP_598415.1  hematopoietic progenitor cell antigen CD34 isoform 2 precursor

    See identical proteins and their annotated locations for NP_598415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a longer C-terminus compared to isoform 1.
    Source sequence(s)
    AK044121, AK053874, AV319386, BU058977, BY249301, BY327943
    Consensus CDS
    CCDS15640.1
    UniProtKB/Swiss-Prot
    Q64314
    UniProtKB/TrEMBL
    Q543B6, Q543Y2
    Related
    ENSMUSP00000016638.3, ENSMUST00000016638.8
    Conserved Domains (1) summary
    pfam06365
    Location:187381
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194621129..194643600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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