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CD34 CD34 molecule [ Homo sapiens (human) ]

Gene ID: 947, updated on 8-Dec-2018

Summary

Official Symbol
CD34provided by HGNC
Official Full Name
CD34 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1662
See related
Ensembl:ENSG00000174059 MIM:142230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in placenta (RPKM 110.3), fat (RPKM 76.9) and 19 other tissues See more
Orthologs

Genomic context

See CD34 in Genome Data Viewer
Location:
1q32.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (207886538..207911338, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208059883..208084742, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR29B2 and MIR29C host gene Neighboring gene microRNA 29b-2 Neighboring gene uncharacterized LOC148696 Neighboring gene uncharacterized LOC107985253 Neighboring gene uncharacterized LOC105372883 Neighboring gene plexin A2 Neighboring gene uncharacterized LOC105372887

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants associated with general and MMR vaccine-related febrile seizures.
NHGRI GWA Catalog
Genome-wide association analysis identifies multiple loci related to resting heart rate.
NHGRI GWA Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
NHGRI GWA Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    C-MYB transcription factor network, organism-specific biosystem
    C-MYB transcription factor network
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
sulfate binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell motility IEP
Inferred from Expression Pattern
more info
PubMed 
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
extracellular exosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
glomerular endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
glomerular filtration IEP
Inferred from Expression Pattern
more info
PubMed 
hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
mesangial cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric glomerular mesangial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
paracrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of glial cell-derived neurotrophic factor secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of granulocyte colony-stimulating factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of granulocyte colony-stimulating factor production IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
stem cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
tissue homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
transdifferentiation IEP
Inferred from Expression Pattern
more info
PubMed 
vascular wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IC
Inferred by Curator
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
glomerular endothelium fenestra ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hematopoietic progenitor cell antigen CD34
Names
CD34 antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025109.1NP_001020280.1  hematopoietic progenitor cell antigen CD34 isoform a precursor

    See identical proteins and their annotated locations for NP_001020280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AA022917, BC039146, M81104
    Consensus CDS
    CCDS31011.1
    UniProtKB/Swiss-Prot
    P28906
    Related
    ENSP00000310036.7, ENST00000310833.11
    Conserved Domains (1) summary
    pfam06365
    Location:190384
    CD34_antigen; CD34/Podocalyxin family
  2. NM_001773.2NP_001764.1  hematopoietic progenitor cell antigen CD34 isoform b precursor

    See identical proteins and their annotated locations for NP_001764.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA022917, AL356275, BC039146, M81104
    Consensus CDS
    CCDS31012.1
    UniProtKB/Swiss-Prot
    P28906
    Related
    ENSP00000348916.4, ENST00000356522.4
    Conserved Domains (1) summary
    pfam06365
    Location:190328
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    207886538..207911338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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