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Cct6b chaperonin containing Tcp1, subunit 6b (zeta) [ Mus musculus (house mouse) ]

Gene ID: 12467, updated on 4-Dec-2022

Summary

Official Symbol
Cct6bprovided by MGI
Official Full Name
chaperonin containing Tcp1, subunit 6b (zeta)provided by MGI
Primary source
MGI:MGI:1329013
See related
Ensembl:ENSMUSG00000020698 AllianceGenome:MGI:1329013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cctz-2; CCTzeta-2; CCT-zeta-2; TCP-1-zeta-2
Summary
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within toxin transport. Part of chaperonin-containing T-complex. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 23.6) See more
Orthologs
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Genomic context

See Cct6b in Genome Data Viewer
Location:
11; 11 C
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82603938..82655154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82713112..82764388, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24612 Neighboring gene predicted gene 11426 Neighboring gene GTP binding protein 3 pseudogene Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene zinc finger protein 830 Neighboring gene predicted gene 11423

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit zeta-2
Names
chaperonin subunit 6b (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291242.1NP_001278171.1  T-complex protein 1 subunit zeta-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5'-terminal exon, which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK076639, BC100457, CF551313
    Consensus CDS
    CCDS70265.1
    UniProtKB/TrEMBL
    B1AT05, Q497N0, Q8BVT1
    Related
    ENSMUSP00000098288.5, ENSMUST00000100722.5
    Conserved Domains (2) summary
    cd03342
    Location:7487
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:7491
    chap_CCT_zeta; T-complex protein 1, zeta subunit
  2. NM_009839.3NP_033969.2  T-complex protein 1 subunit zeta-2 isoform 1

    See identical proteins and their annotated locations for NP_033969.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK076639, BC100457, CF551313
    Consensus CDS
    CCDS25145.1
    UniProtKB/Swiss-Prot
    Q61390, Q9R1U2
    UniProtKB/TrEMBL
    Q497N0, Q8BVT1
    Related
    ENSMUSP00000021040.4, ENSMUST00000021040.10
    Conserved Domains (2) summary
    cd03342
    Location:8526
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82603938..82655154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245508.2XP_030101368.1  T-complex protein 1 subunit zeta-2 isoform X3

    Conserved Domains (1) summary
    cd03342
    Location:7416
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
  2. XM_006532108.3XP_006532171.1  T-complex protein 1 subunit zeta-2 isoform X2

    Conserved Domains (1) summary
    cd03342
    Location:8455
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
  3. XM_006532107.4XP_006532170.1  T-complex protein 1 subunit zeta-2 isoform X1

    Conserved Domains (1) summary
    TIGR02347
    Location:1464
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RNA

  1. XR_001779867.3 RNA Sequence

  2. XR_879512.3 RNA Sequence

  3. XR_003949272.2 RNA Sequence