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CCT6B chaperonin containing TCP1 subunit 6B [ Homo sapiens (human) ]

Gene ID: 10693, updated on 4-Jul-2021

Summary

Official Symbol
CCT6Bprovided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 6Bprovided by HGNC
Primary source
HGNC:HGNC:1621
See related
Ensembl:ENSG00000132141 MIM:610730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2
Summary
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in testis (RPKM 57.4) and thyroid (RPKM 1.2) See more
Orthologs
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Genomic context

See CCT6B in Genome Data Viewer
Location:
17q12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (34927861..34981222, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33254880..33288479, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371740 Neighboring gene uncharacterized LOC105371742 Neighboring gene uncharacterized LOC105371741 Neighboring gene zinc finger protein 830 Neighboring gene RAD51L3-RFFL readthrough Neighboring gene DNA ligase 3 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 7 Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene ribosomal protein L37 pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toxin transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit zeta-2
Names
chaperonin containing TCP1, subunit 6B (zeta 2)
chaperonin-containing T-complex polypeptide 1, subunit 6B
testis-specific Tcp20
testis-specific protein TSA303

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193529.3NP_001180458.1  T-complex protein 1 subunit zeta-2 isoform 2

    See identical proteins and their annotated locations for NP_001180458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK301773, DB032371
    Consensus CDS
    CCDS54106.1
    UniProtKB/Swiss-Prot
    Q92526
    Related
    ENSP00000398044.3, ENST00000421975.7
    Conserved Domains (2) summary
    cd03342
    Location:23489
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3493
    chap_CCT_zeta; T-complex protein 1, zeta subunit
  2. NM_001193530.2NP_001180459.1  T-complex protein 1 subunit zeta-2 isoform 3

    See identical proteins and their annotated locations for NP_001180459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK301773, AK302344, BC027591, DB032371
    Consensus CDS
    CCDS54105.1
    UniProtKB/Swiss-Prot
    Q92526
    Related
    ENSP00000400917.3, ENST00000436961.7
    Conserved Domains (2) summary
    cd03342
    Location:23481
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3485
    chap_CCT_zeta; T-complex protein 1, zeta subunit
  3. NM_006584.4NP_006575.2  T-complex protein 1 subunit zeta-2 isoform 1

    See identical proteins and their annotated locations for NP_006575.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK301773, BC026125, DB032371
    Consensus CDS
    CCDS32617.1
    UniProtKB/Swiss-Prot
    Q92526
    Related
    ENSP00000327191.5, ENST00000314144.10
    Conserved Domains (2) summary
    cd03342
    Location:23526
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    34927861..34981222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024023.2XP_016879512.1  T-complex protein 1 subunit zeta-2 isoform X1

  2. XM_011524203.3XP_011522505.1  T-complex protein 1 subunit zeta-2 isoform X2

    Conserved Domains (1) summary
    cl02777
    Location:3384
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  3. XM_017024024.2XP_016879513.1  T-complex protein 1 subunit zeta-2 isoform X3

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