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Cct6a chaperonin containing TCP1 subunit 6A [ Mus musculus (house mouse) ]

Gene ID: 12466, updated on 9-May-2024

Summary

Official Symbol
Cct6aprovided by MGI
Official Full Name
chaperonin containing TCP1 subunit 6Aprovided by MGI
Primary source
MGI:MGI:107943
See related
Ensembl:ENSMUSG00000029447 AllianceGenome:MGI:107943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cct6; Cctz-1; CCT-zeta; CCT-zeta-1; TCP-1-zeta
Summary
Predicted to enable WD40-repeat domain binding activity; protein folding chaperone; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in acrosomal vesicle and cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in 8-cell stage embryo. Orthologous to human CCT6A (chaperonin containing TCP1 subunit 6A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene aligns across a gap in the GRCm38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_039313.8 and the 3' end was annotated on NT_039314.8 in NCBI's Mus Musculus Annotation Release 105. [15 Jun 2015]
Expression
Broad expression in CNS E11.5 (RPKM 106.6), placenta adult (RPKM 82.3) and 24 other tissues See more
Orthologs
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Genomic context

See Cct6a in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129864420..129875284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129787356..129846443)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 2 Neighboring gene STARR-seq mESC enhancer starr_14458 Neighboring gene STARR-seq mESC enhancer starr_14459 Neighboring gene phosphoserine phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E854 Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables WD40-repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit zeta
Names
chaperonin containing TCP-1
chaperonin containing Tcp1, subunit 6a (zeta)
chaperonin subunit 6a (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009838.3NP_033968.2  T-complex protein 1 subunit zeta

    Status: VALIDATED

    Source sequence(s)
    MG954262
    UniProtKB/TrEMBL
    Q3TIX8, Q3TW97, Q52KG9
    Related
    ENSMUSP00000159385.2, ENSMUST00000201414.5
    Conserved Domains (1) summary
    TIGR02347
    Location:3530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129864420..129875284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)