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CCT6A chaperonin containing TCP1 subunit 6A [ Homo sapiens (human) ]

Gene ID: 908, updated on 3-Nov-2019

Summary

Official Symbol
CCT6Aprovided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 6Aprovided by HGNC
Primary source
HGNC:HGNC:1620
See related
Ensembl:ENSG00000146731 MIM:104613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues See more
Orthologs

Genomic context

See CCT6A in Genome Data Viewer
Location:
7p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (56051765..56063989)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (56119378..56131682)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 2 Neighboring gene phosphoserine phosphatase Neighboring gene small nucleolar RNA, H/ACA box 22B Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase catalytic subunit gamma 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of chaperonin containing TCP1, subunit 6A (CCT6A) in the nucleoli of Jurkat T-cells PubMed
Vif vif HIV-1 Vif interacts with CCT6A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126214, MGC126215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
WD40-repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit zeta
Names
T-complex protein 1, zeta subunit
acute morphine dependence related protein 2
amino acid transport defect-complementing
chaperonin containing T-complex subunit 6
chaperonin containing TCP1, subunit 6A (zeta 1)
histidine transport regulator 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009186.2NP_001009186.1  T-complex protein 1 subunit zeta isoform b

    See identical proteins and their annotated locations for NP_001009186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AC092101, AW411253, BI464886, BU540578
    Consensus CDS
    CCDS34640.1
    UniProtKB/Swiss-Prot
    P40227
    Related
    ENSP00000352019.2, ENST00000335503.3
    Conserved Domains (1) summary
    cl02777
    Location:3485
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  2. NM_001762.4NP_001753.1  T-complex protein 1 subunit zeta isoform a

    See identical proteins and their annotated locations for NP_001753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC092101, AC092579, AW411253, BI464886
    Consensus CDS
    CCDS5523.1
    UniProtKB/Swiss-Prot
    P40227
    UniProtKB/TrEMBL
    A0A024RDL1
    Related
    ENSP00000275603.4, ENST00000275603.9
    Conserved Domains (1) summary
    TIGR02347
    Location:3530
    chap_CCT_zeta; T-complex protein 1, zeta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    56051765..56063989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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