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Cct4 chaperonin containing TCP1 subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 12464, updated on 5-Mar-2024

Summary

Official Symbol
Cct4provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 4provided by MGI
Primary source
MGI:MGI:104689
See related
Ensembl:ENSMUSG00000007739 AllianceGenome:MGI:104689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A45; Cctd; 2610204B21Rik
Summary
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 82.4), placenta adult (RPKM 69.7) and 28 other tissues See more
Orthologs
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Genomic context

See Cct4 in Genome Data Viewer
Location:
11 A3.2; 11 14.25 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (22940593..22953336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (22990593..23003336)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24917 Neighboring gene STARR-seq mESC enhancer starr_28892 Neighboring gene COMM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3935 Neighboring gene STARR-seq mESC enhancer starr_28894 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E10666 Neighboring gene STARR-seq mESC enhancer starr_28896 Neighboring gene STARR-seq mESC enhancer starr_28897 Neighboring gene STARR-positive B cell enhancer ABC_E9817 Neighboring gene family with sequence similarity 161, member A Neighboring gene STARR-seq mESC enhancer starr_28898 Neighboring gene STARR-seq mESC enhancer starr_28899 Neighboring gene predicted gene 12059

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit delta
Names
CCT-delta
T complex protein 1, delta
TCP-1-delta
chaperonin containing Tcp1, subunit 4 (delta)
chaperonin subunit 4 (delta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009837.1NP_033967.1  T-complex protein 1 subunit delta

    See identical proteins and their annotated locations for NP_033967.1

    Status: VALIDATED

    Source sequence(s)
    Z31554
    Consensus CDS
    CCDS24474.1
    UniProtKB/Swiss-Prot
    P80315
    UniProtKB/TrEMBL
    Q3TII0, Q3UJZ8, Q564F4
    Related
    ENSMUSP00000133523.2, ENSMUST00000173867.8
    Conserved Domains (2) summary
    cd03338
    Location:25538
    TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    pfam00118
    Location:44539
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    22940593..22953336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)