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CCT4 chaperonin containing TCP1 subunit 4 [ Homo sapiens (human) ]

Gene ID: 10575, updated on 3-Nov-2019

Summary

Official Symbol
CCT4provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 4provided by HGNC
Primary source
HGNC:HGNC:1617
See related
Ensembl:ENSG00000115484 MIM:605142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB; Cctd; CCT-DELTA
Summary
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues See more
Orthologs

Genomic context

See CCT4 in Genome Data Viewer
Location:
2p15
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (61868085..61888671, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (62095262..62115806, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene serine and arginine repetitive matrix 1 pseudogene Neighboring gene ribosomal protein L31 pseudogene 30 Neighboring gene copper metabolism domain containing 1 Neighboring gene uncharacterized LOC107985768 Neighboring gene ribosomal protein SA pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Stimulator of TAR RNA-binding proteins (SRB) stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between SRB and HIV-1 Tat PubMed
Vif vif HIV-1 Vif interacts with CCT4 PubMed
integrase gag-pol Interaction of human CCT4 with HIV-1 integrase is presumed based on a reported binding interaction between yeast CCT4 and integrase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126164, MGC126165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit delta
Names
TCP-1-delta
chaperonin containing TCP1, subunit 4 (delta)
chaperonin containing t-complex polypeptide 1, delta subunit
stimulator of TAR RNA-binding

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256721.1NP_001243650.1  T-complex protein 1 subunit delta isoform b

    See identical proteins and their annotated locations for NP_001243650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AA136129, AI439570, AK303082, BM765256, DB461009
    Consensus CDS
    CCDS58711.1
    UniProtKB/Swiss-Prot
    P50991
    Related
    ENSP00000443061.1, ENST00000544079.2
    Conserved Domains (1) summary
    cd03338
    Location:25508
    TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
  2. NM_006430.4NP_006421.2  T-complex protein 1 subunit delta isoform a

    See identical proteins and their annotated locations for NP_006421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (a).
    Source sequence(s)
    AC107081, AI439570, BC106934, DB461009
    Consensus CDS
    CCDS33206.1
    UniProtKB/Swiss-Prot
    P50991
    Related
    ENSP00000377958.3, ENST00000394440.8
    Conserved Domains (1) summary
    cd03338
    Location:25538
    TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    61868085..61888671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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