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Cck cholecystokinin [ Mus musculus (house mouse) ]

Gene ID: 12424, updated on 5-Jan-2023

Summary

Official Symbol
Cckprovided by MGI
Official Full Name
cholecystokininprovided by MGI
Primary source
MGI:MGI:88297
See related
Ensembl:ENSMUSG00000032532 AllianceGenome:MGI:88297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Biased expression in cortex adult (RPKM 201.9), frontal lobe adult (RPKM 179.3) and 6 other tissues See more
Orthologs
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Genomic context

See Cck in Genome Data Viewer
Location:
9 72.43 cM; 9 F4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121318890..121324760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121489824..121495694, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1661 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene predicted gene, 51661 Neighboring gene predicted gene, 38661 Neighboring gene predicted gene, 47095 Neighboring gene lysozyme-like 4 Neighboring gene lysozyme-like 4, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in digestion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within eating behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic signaling via neuropeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284508.3NP_001271437.1  cholecystokinin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271437.1

    Status: VALIDATED

    Source sequence(s)
    AC131660
    Consensus CDS
    CCDS90686.1
    UniProtKB/Swiss-Prot
    P09240
    UniProtKB/TrEMBL
    Q8R041
    Related
    ENSMUSP00000150080.2, ENSMUST00000216138.2
    Conserved Domains (1) summary
    cl27628
    Location:471
    Gastrin; Gastrin/cholecystokinin family
  2. NM_001410236.1NP_001397165.1  cholecystokinin isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC131660
    UniProtKB/Swiss-Prot
    Q9DCL5
    UniProtKB/TrEMBL
    A0A8C6N0W2
  3. NM_031161.5NP_112438.1  cholecystokinin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_112438.1

    Status: VALIDATED

    Source sequence(s)
    AC131660
    Consensus CDS
    CCDS23631.1
    UniProtKB/Swiss-Prot
    P09240, Q9DCL5
    UniProtKB/TrEMBL
    A0A8C6N0W2
    Related
    ENSMUSP00000035120.5, ENSMUST00000035120.6
    Conserved Domains (1) summary
    pfam00918
    Location:4115
    Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121318890..121324760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313116.2XP_017168605.1  cholecystokinin isoform X1

    UniProtKB/Swiss-Prot
    P09240
    Related
    ENSMUSP00000149679.2, ENSMUST00000215228.2
    Conserved Domains (1) summary
    pfam00918
    Location:4115
    Gastrin; Gastrin/cholecystokinin family