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CCK cholecystokinin [ Homo sapiens (human) ]

Gene ID: 885, updated on 24-Nov-2020

Summary

Official Symbol
CCKprovided by HGNC
Official Full Name
cholecystokininprovided by HGNC
Primary source
HGNC:HGNC:1569
See related
Ensembl:ENSG00000187094 MIM:118440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Biased expression in duodenum (RPKM 21.7), brain (RPKM 20.3) and 2 other tissues See more
Orthologs

Genomic context

See CCK in Genome Data Viewer
Location:
3p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (42257826..42266185, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42299315..42307662, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene trafficking kinesin protein 1 Neighboring gene RNA, U4 small nuclear 78, pseudogene Neighboring gene uncharacterized LOC105377048 Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
GeneReviews: Not available
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117187

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
digestion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eating behavior ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
negative regulation of behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of eating behavior IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axon hillock IEA
Inferred from Electronic Annotation
more info
 
axon initial segment IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cholecystokinin
Names
cholecystokinin triacontatriapeptide
prepro-cholecystokinin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000729.6NP_000720.1  cholecystokinin preproprotein

    See identical proteins and their annotated locations for NP_000720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC018358, BC111026, BI756101, BM544754, CB154424, HY140623
    Consensus CDS
    CCDS2696.1
    UniProtKB/Swiss-Prot
    P06307
    UniProtKB/TrEMBL
    Q6FG82
    Related
    ENSP00000379472.2, ENST00000396169.7
    Conserved Domains (1) summary
    pfam00918
    Location:4115
    Gastrin; Gastrin/cholecystokinin family
  2. NM_001174138.3NP_001167609.1  cholecystokinin preproprotein

    See identical proteins and their annotated locations for NP_001167609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC008283
    Consensus CDS
    CCDS2696.1
    UniProtKB/Swiss-Prot
    P06307
    UniProtKB/TrEMBL
    Q6FG82
    Related
    ENSP00000409124.1, ENST00000434608.1
    Conserved Domains (1) summary
    pfam00918
    Location:4115
    Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    42257826..42266185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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