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PAQR4 progestin and adipoQ receptor family member 4 [ Homo sapiens (human) ]

Gene ID: 124222, updated on 23-Nov-2021

Summary

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Official Symbol
PAQR4provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 4provided by HGNC
Primary source
HGNC:HGNC:26386
See related
Ensembl:ENSG00000162073 MIM:614578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 16.0), bone marrow (RPKM 6.3) and 22 other tissues See more
Orthologs
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Genomic context

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See PAQR4 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2969348..2973484)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3019349..3023485)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene uncharacterized LOC105371055 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene glycine rich extracellular protein 1 Neighboring gene Sharpr-MPRA regulatory region 11969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. Pedersen L, et al. Cancer Res, 2020 Jun 1. PMID 32291319
  2. MicroRNA-370 inhibits the proliferation, invasion and EMT of gastric cancer cells by directly targeting PAQR4. Feng Y, et al. J Pharmacol Sci, 2018 Oct. PMID 30322804
  3. PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation. Zhang H, et al. Carcinogenesis, 2018 Mar 8. PMID 29228296
  4. PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation. Xu P, et al. Theranostics, 2020. PMID 32206121, Free PMC Article
  5. The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis. Wang L, et al. J Mol Cell Biol, 2017 Oct 1. PMID 28992327

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.
    Title: PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.
  2. Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer.
    Title: Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer.
  3. PAQR4 (Progestin and AdipoQ Receptor 4) expression is closely associated with progression of many cancers and microRNA (miRNA) processing.
    Title: MicroRNA-370 inhibits the proliferation, invasion and EMT of gastric cancer cells by directly targeting PAQR4.
  4. Data indicate that PAQR4 has a tumorigenic effect on human breast cancers, and such effect is associated with a modulatory activity of PAQR4 on protein degradation of CDK4
    Title: PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide association study of the metabolic syndrome in Indian Asian men.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ30002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
progestin and adipoQ receptor family member 4
Names
progestin and adipoQ receptor family member IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284511.2 → NP_001271440.1  progestin and adipoQ receptor family member 4 isoform 2

    See identical proteins and their annotated locations for NP_001271440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004235, AK054564, AL832527
    Consensus CDS
    CCDS66911.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    Related
    ENSP00000293978.8, ENST00000293978.12
    Conserved Domains (1) summary
    cl03831
    Location:43 → 215
    HlyIII; Haemolysin-III related

  2. NM_001284512.2 → NP_001271441.1  progestin and adipoQ receptor family member 4 isoform 3

    See identical proteins and their annotated locations for NP_001271441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC004235, AK054564, AL832527
    Consensus CDS
    CCDS66912.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    UniProtKB/TrEMBL
    I3L265
    Related
    ENSP00000459418.1, ENST00000572687.1
    Conserved Domains (1) summary
    cl03831
    Location:57 → 180
    HlyIII; Haemolysin-III related

  3. NM_001284513.2 → NP_001271442.1  progestin and adipoQ receptor family member 4 isoform 4

    See identical proteins and their annotated locations for NP_001271442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL832527, BQ935501
    Consensus CDS
    CCDS73814.1
    UniProtKB/TrEMBL
    I3L1A2
    Related
    ENSP00000460326.1, ENST00000576565.1
    Conserved Domains (1) summary
    cl03831
    Location:29 → 187
    HlyIII; Haemolysin-III related

  4. NM_001324118.2 → NP_001311047.1  progestin and adipoQ receptor family member 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004235
    Conserved Domains (1) summary
    cl03831
    Location:43 → 162
    HlyIII; Haemolysin-III related

  5. NM_152341.5 → NP_689554.2  progestin and adipoQ receptor family member 4 isoform 1

    See identical proteins and their annotated locations for NP_689554.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004235, AL832527, BC033703
    Consensus CDS
    CCDS10485.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    Related
    ENSP00000321804.8, ENST00000318782.9
    Conserved Domains (1) summary
    cl03831
    Location:43 → 254
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2969348..2973484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N4S7.3 GenPept UniProtKB/Swiss-Prot:Q8N4S7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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