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PAQR4 progestin and adipoQ receptor family member 4 [ Homo sapiens (human) ]

Gene ID: 124222, updated on 23-Nov-2021

Summary

Official Symbol
PAQR4provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 4provided by HGNC
Primary source
HGNC:HGNC:26386
See related
Ensembl:ENSG00000162073 MIM:614578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 16.0), bone marrow (RPKM 6.3) and 22 other tissues See more
Orthologs
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Genomic context

See PAQR4 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2969348..2973484)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3019349..3023485)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene uncharacterized LOC105371055 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene glycine rich extracellular protein 1 Neighboring gene Sharpr-MPRA regulatory region 11969

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of the metabolic syndrome in Indian Asian men.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ30002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
progestin and adipoQ receptor family member 4
Names
progestin and adipoQ receptor family member IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284511.2NP_001271440.1  progestin and adipoQ receptor family member 4 isoform 2

    See identical proteins and their annotated locations for NP_001271440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004235, AK054564, AL832527
    Consensus CDS
    CCDS66911.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    Related
    ENSP00000293978.8, ENST00000293978.12
    Conserved Domains (1) summary
    cl03831
    Location:43215
    HlyIII; Haemolysin-III related
  2. NM_001284512.2NP_001271441.1  progestin and adipoQ receptor family member 4 isoform 3

    See identical proteins and their annotated locations for NP_001271441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC004235, AK054564, AL832527
    Consensus CDS
    CCDS66912.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    UniProtKB/TrEMBL
    I3L265
    Related
    ENSP00000459418.1, ENST00000572687.1
    Conserved Domains (1) summary
    cl03831
    Location:57180
    HlyIII; Haemolysin-III related
  3. NM_001284513.2NP_001271442.1  progestin and adipoQ receptor family member 4 isoform 4

    See identical proteins and their annotated locations for NP_001271442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL832527, BQ935501
    Consensus CDS
    CCDS73814.1
    UniProtKB/TrEMBL
    I3L1A2
    Related
    ENSP00000460326.1, ENST00000576565.1
    Conserved Domains (1) summary
    cl03831
    Location:29187
    HlyIII; Haemolysin-III related
  4. NM_001324118.2NP_001311047.1  progestin and adipoQ receptor family member 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004235
    Conserved Domains (1) summary
    cl03831
    Location:43162
    HlyIII; Haemolysin-III related
  5. NM_152341.5NP_689554.2  progestin and adipoQ receptor family member 4 isoform 1

    See identical proteins and their annotated locations for NP_689554.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004235, AL832527, BC033703
    Consensus CDS
    CCDS10485.1
    UniProtKB/Swiss-Prot
    Q8N4S7
    Related
    ENSP00000321804.8, ENST00000318782.9
    Conserved Domains (1) summary
    cl03831
    Location:43254
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2969348..2973484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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