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Ctnnd1 catenin (cadherin associated protein), delta 1 [ Mus musculus (house mouse) ]

Gene ID: 12388, updated on 8-Jan-2023

Summary

Official Symbol
Ctnnd1provided by MGI
Official Full Name
catenin (cadherin associated protein), delta 1provided by MGI
Primary source
MGI:MGI:105100
See related
Ensembl:ENSMUSG00000034101 AllianceGenome:MGI:105100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P120; Catns; Ctnnd; mKIAA0384
Summary
Enables protein domain specific binding activity and protein phosphatase binding activity. Acts upstream of or within several processes, including glomerulus morphogenesis; positive regulation of cellular protein metabolic process; and salivary gland development. Located in several cellular components, including adherens junction; apicolateral plasma membrane; and bicellular tight junction. Part of flotillin complex. Is expressed in several structures, including 4-8 cell stage embryo; alimentary system; central nervous system; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 34.1), large intestine adult (RPKM 31.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ctnnd1 in Genome Data Viewer
Location:
2 D; 2 49.45 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84417440..84489321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84587096..84658977, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13710 Neighboring gene VISTA enhancer mm1324 Neighboring gene BTB (POZ) domain containing 18 Neighboring gene selenoprotein H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation involved in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine autophosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
part_of flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in zonula adherens ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
catenin delta-1
Names
CAS
cadherin-associated Src substrate
catenin src
p120 catenin
p120(cas)
p120(ctn)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085448.1NP_001078917.1  catenin delta-1 isoform 2

    See identical proteins and their annotated locations for NP_001078917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' UTR segment and an alternate exon in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter than isoform 1. Variants 3 and 7 both encode the same isoform (2).
    Source sequence(s)
    AK133193, AK161790, AL929079, BC043108, BY422861
    Consensus CDS
    CCDS50623.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000107326.3, ENSMUST00000111697.9
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  2. NM_001085449.1NP_001078918.1  catenin delta-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK161790, AK168453, AL929079, BC043108, BY422861
    Consensus CDS
    CCDS50621.1
    UniProtKB/Swiss-Prot
    P30999
    UniProtKB/TrEMBL
    E9Q986
    Related
    ENSMUSP00000107299.3, ENSMUST00000111670.9
    Conserved Domains (2) summary
    cd00020
    Location:262380
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:267292
    ARM; armadillo repeat [structural motif]
  3. NM_001085450.1NP_001078919.1  catenin delta-1 isoform 1

    See identical proteins and their annotated locations for NP_001078919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR compared to variant 1. Variants 1, 2, and 6 all encode the same isoform (1).
    Source sequence(s)
    BC043108, BY422861, CJ174738
    Consensus CDS
    CCDS16186.1
    UniProtKB/Swiss-Prot
    P30999, Q8CHF8
    Related
    ENSMUSP00000107320.2, ENSMUST00000111691.2
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  4. NM_001085453.2NP_001078922.1  catenin delta-1 isoform 4

    See identical proteins and their annotated locations for NP_001078922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variant 5 is also known as CAS 1B.
    Source sequence(s)
    AL928616, AL929079
    Consensus CDS
    CCDS50622.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000065252.4, ENSMUST00000066177.10
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  5. NM_001355064.1NP_001341993.1  catenin delta-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 2, encodes isoform 1.
    Source sequence(s)
    AK133193, AL928616, AL929079
    Consensus CDS
    CCDS16186.1
    UniProtKB/Swiss-Prot
    Q8CHF8
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  6. NM_001355065.1NP_001341994.1  catenin delta-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 3, encodes isoform 2.
    Source sequence(s)
    AB093237, AL928616, AL929079
    Consensus CDS
    CCDS50623.1
    Related
    ENSMUSP00000042543.7, ENSMUST00000036811.13
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  7. NM_001355066.1NP_001341995.1  catenin delta-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928616, AL929079
    Consensus CDS
    CCDS89504.1
    UniProtKB/TrEMBL
    G3X9V2
    Related
    ENSMUSP00000107321.2, ENSMUST00000111692.8
    Conserved Domains (2) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  8. NM_001355067.1NP_001341996.1  catenin delta-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928616, AL929079
    Related
    ENSMUSP00000107306.2, ENSMUST00000111677.8
    Conserved Domains (2) summary
    smart00185
    Location:296336
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:267292
    ARM; armadillo repeat [structural motif]
  9. NM_007615.4NP_031641.2  catenin delta-1 isoform 1

    See identical proteins and their annotated locations for NP_031641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2, and 6 all encode the same isoform (1).
    Source sequence(s)
    BC043108, BC054544, BY422861, CJ174738
    Consensus CDS
    CCDS16186.1
    UniProtKB/Swiss-Prot
    P30999, Q8CHF8
    Related
    ENSMUSP00000064518.4, ENSMUST00000067232.10
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84417440..84489321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498630.2XP_006498693.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006498693.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  2. XM_006498639.5XP_006498702.1  catenin delta-1 isoform X12

    UniProtKB/TrEMBL
    E9Q905
    Related
    ENSMUSP00000107307.2, ENSMUST00000111678.8
    Conserved Domains (3) summary
    smart00185
    Location:296336
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:531639
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:267292
    ARM; armadillo repeat [structural motif]
  3. XM_036157836.1XP_036013729.1  catenin delta-1 isoform X11

    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  4. XM_006498634.4XP_006498697.1  catenin delta-1 isoform X5

    UniProtKB/TrEMBL
    E9Q8Z5
    Related
    ENSMUSP00000107325.2, ENSMUST00000111696.8
    Conserved Domains (2) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  5. XM_030247019.2XP_030102879.1  catenin delta-1 isoform X7

    Conserved Domains (2) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  6. XM_006498632.4XP_006498695.1  catenin delta-1 isoform X3

    UniProtKB/TrEMBL
    E9Q8Z6
    Related
    ENSMUSP00000107324.2, ENSMUST00000111695.8
    Conserved Domains (2) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  7. XM_006498638.3XP_006498701.1  catenin delta-1 isoform X9

    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  8. XM_006498633.4XP_006498696.1  catenin delta-1 isoform X4

    Related
    ENSMUSP00000107314.2, ENSMUST00000111685.8
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  9. XM_006498636.4XP_006498699.1  catenin delta-1 isoform X6

    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  10. XM_006498631.4XP_006498694.1  catenin delta-1 isoform X2

    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  11. XM_006498625.4XP_006498688.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006498688.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Related
    ENSMUSP00000107313.2, ENSMUST00000111684.8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  12. XM_036157835.1XP_036013728.1  catenin delta-1 isoform X10

    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  13. XM_017315208.3XP_017170697.1  catenin delta-1 isoform X8

    UniProtKB/Swiss-Prot
    P30999
    Conserved Domains (3) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
  14. XM_006498626.5XP_006498689.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006498689.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Related
    ENSMUSP00000107323.2, ENSMUST00000111694.8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  15. XM_017315179.3XP_017170668.1  catenin delta-1 isoform X1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  16. XM_036157823.1XP_036013716.1  catenin delta-1 isoform X1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat
  17. XM_006498628.5XP_006498691.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006498691.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (4) summary
    smart00185
    Location:397437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440481
    Arm; Armadillo/beta-catenin-like repeat