Casp7 caspase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp7provided by MGI
Official Full Name: caspase 7provided by MGI
Primary source: MGI:MGI:109383
See related: Ensembl:ENSMUSG00000025076 AllianceGenome:MGI:109383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7
Summary: Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including execution phase of apoptosis; neuron apoptotic process; and response to UV. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; foregut; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 48.3), duodenum adult (RPKM 25.6) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19 D2; 19 51.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (56382640..56430780)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (56396833..56442348)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caspase-7 activates ASM to repair gasdermin and perforin pores.
Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
Title: Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
The signaling was mediated by caspase-7-induced down-regulation of the microRNA-133a (miR-133a) and consequent up-regulation of Ras homolog family member A and myosin light-chain phosphorylation.
Title: Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.
caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7/PARP1/AIF pathway.
Title: Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
Caspases and their substrates are key mediators of apoptosis.
Title: Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.
caspase-1 activation is an upstream event of apoptotic caspase-7 induction in renal tubulointerstitial fibrosis
Title: Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis.
Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3/7, in a dose-dependent fashion.
Title: Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells.
Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction.
Title: Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis.
does not significantly contribute to cardiomyocyte death induced by transient coronary occlusion
Title: Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling.
Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
Title: Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI314680 (e-PCR)
- UniSTS:160861

Casp7 (e-PCR), detects polymorphism
- UniSTS:515960

Homology

Homologs of the Casp7 gene: The Casp7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 480 organisms have orthologs with human gene Casp7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to staurosporine	ISO Inferred from Sequence Orthology more info
acts_upstream_of defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within execution phase of apoptosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within fibroblast apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of plasma membrane repair	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within response to UV	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of caspase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: caspase-7

Names: CASP-7; apoptotic protease Mch-3; cysteine protease LICE2

NP_031637.1

EC 3.4.22.60

XP_006526679.3

EC 3.4.22.60

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007611.3 → NP_031637.1 caspase-7 precursor

See identical proteins and their annotated locations for NP_031637.1

Status: VALIDATED

Source sequence(s)

AC115771, AC166746

Consensus CDS

CCDS29915.1

UniProtKB/Swiss-Prot

O08669, P97864

UniProtKB/TrEMBL

Q4FJQ4

Related

ENSMUSP00000026062.10, ENSMUST00000026062.10

Conserved Domains (1) summary

cd00032
Location:60 → 301

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

56382640..56430780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526616.5 → XP_006526679.3 caspase-7 isoform X1

Conserved Domains (1) summary

cd00032
Location:107 → 348

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...