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Casp7 caspase 7 [ Mus musculus (house mouse) ]

Gene ID: 12369, updated on 5-Jan-2023

Summary

Official Symbol
Casp7provided by MGI
Official Full Name
caspase 7provided by MGI
Primary source
MGI:MGI:109383
See related
Ensembl:ENSMUSG00000025076 AllianceGenome:MGI:109383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7
Summary
Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including execution phase of apoptosis; neuron apoptotic process; and response to UV. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; foregut; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 48.3), duodenum adult (RPKM 25.6) and 22 other tissues See more
Orthologs
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Genomic context

See Casp7 in Genome Data Viewer
Location:
19 D2; 19 51.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56382640..56430780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56396833..56442348)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32257 Neighboring gene hyaluronic acid binding protein 2 Neighboring gene nebulin-related anchoring protein Neighboring gene predicted gene 17197 Neighboring gene predicted gene, 46657 Neighboring gene pleckstrin homology domain containing, family S member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to staurosporine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within execution phase of apoptosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within fibroblast apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
acts_upstream_of_or_within response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of caspase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase-7
Names
CASP-7
apoptotic protease Mch-3
cysteine protease LICE2
NP_031637.1
XP_006526679.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007611.3NP_031637.1  caspase-7 precursor

    See identical proteins and their annotated locations for NP_031637.1

    Status: VALIDATED

    Source sequence(s)
    AC115771, AC166746
    Consensus CDS
    CCDS29915.1
    UniProtKB/Swiss-Prot
    O08669, P97864
    UniProtKB/TrEMBL
    Q4FJQ4
    Related
    ENSMUSP00000026062.10, ENSMUST00000026062.10
    Conserved Domains (1) summary
    cd00032
    Location:60301
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56382640..56430780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526616.5XP_006526679.3  caspase-7 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:107348
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...