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Casp7 caspase 7 [ Mus musculus (house mouse) ]

Gene ID: 12369, updated on 5-Jul-2025
Official Symbol
Casp7provided by MGI
Official Full Name
caspase 7provided by MGI
Primary source
MGI:MGI:109383
See related
Ensembl:ENSMUSG00000025076 AllianceGenome:MGI:109383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7
Summary
Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity. Involved in lymphocyte apoptotic process and protein maturation. Acts upstream of or within several processes, including ceramide biosynthetic process; fibroblast apoptotic process; and plasma membrane repair. Is active in extracellular space. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in large intestine adult (RPKM 48.3), duodenum adult (RPKM 25.6) and 22 other tissues See more
Orthologs
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See Casp7 in Genome Data Viewer
Location:
19 D2; 19 51.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56382640..56430780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56396833..56442348)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32257 Neighboring gene hyaluronic acid binding protein 2 Neighboring gene nebulin-related anchoring protein Neighboring gene predicted gene 17197 Neighboring gene STARR-seq mESC enhancer starr_46523 Neighboring gene predicted gene, 46657 Neighboring gene pleckstrin homology domain containing, family S member 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to staurosporine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to staurosporine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within execution phase of apoptosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fibroblast apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in leukocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of positive regulation of plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
acts_upstream_of_or_within pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
caspase-7
Names
CASP-7
apoptotic protease Mch-3
cysteine protease LICE2
NP_031637.1
XP_006526679.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007611.3NP_031637.1  caspase-7 precursor

    See identical proteins and their annotated locations for NP_031637.1

    Status: VALIDATED

    Source sequence(s)
    AC115771, AC166746
    Consensus CDS
    CCDS29915.1
    UniProtKB/Swiss-Prot
    O08669, P97864
    UniProtKB/TrEMBL
    Q4FJQ4
    Related
    ENSMUSP00000026062.10, ENSMUST00000026062.10
    Conserved Domains (1) summary
    cd00032
    Location:60301
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56382640..56430780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526616.5XP_006526679.3  caspase-7 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:107348
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...