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Capn7 calpain 7 [ Mus musculus (house mouse) ]

Gene ID: 12339, updated on 28-Oct-2019

Summary

Official Symbol
Capn7provided by MGI
Official Full Name
calpain 7provided by MGI
Primary source
MGI:MGI:1338030
See related
Ensembl:ENSMUSG00000021893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PalBH; AU022319
Expression
Ubiquitous expression in CNS E18 (RPKM 22.2), CNS E14 (RPKM 19.2) and 28 other tissues See more
Orthologs

Genomic context

See Capn7 in Genome Data Viewer
Location:
14; 14 B
Exon count:
22
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31336622..31371987)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32149910..32185170)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene Brca1 associated protein 1 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene predicted gene, 35907 Neighboring gene PRELI domain-containing protein 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from BioSystems

  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
MIT domain binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
self proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calpain-7
Names
palB homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360187.1NP_001347116.1  calpain-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB028640, BB855684, BE988205, BF462849, BY143496
    Conserved Domains (3) summary
    smart00720
    Location:643766
    calpain_III; calpain_III domain
    cd00044
    Location:170494
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl00299
    Location:41113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. NM_009796.3NP_033926.1  calpain-7 isoform 1

    See identical proteins and their annotated locations for NP_033926.1

    Status: VALIDATED

    Source sequence(s)
    AB028640, BB855684, BE988205, BF462849
    Consensus CDS
    CCDS26911.1
    UniProtKB/Swiss-Prot
    Q9R1S8
    Related
    ENSMUSP00000022451.7, ENSMUST00000022451.13
    Conserved Domains (4) summary
    smart00720
    Location:687810
    calpain_III; calpain_III domain
    cd00044
    Location:214538
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:576
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85157
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p6 C57BL/6J

    Range
    31336622..31371987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247631.1XP_030103491.1  calpain-7 isoform X1

  2. XM_006518502.3XP_006518565.1  calpain-7 isoform X1

    Conserved Domains (2) summary
    smart00720
    Location:522645
    calpain_III; calpain_III domain
    cd00044
    Location:49373
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

RNA

  1. XR_003950823.1 RNA Sequence

    Related
    ENSMUST00000143472.7
  2. XR_001781094.2 RNA Sequence

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