Caml calcium modulating ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camlprovided by MGI
Official Full Name: calcium modulating ligandprovided by MGI
Primary source: MGI:MGI:104728
See related: Ensembl:ENSMUSG00000021501 AllianceGenome:MGI:104728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Camlg
Summary: Predicted to enable cell adhesion molecule binding activity and ubiquitin protein ligase binding activity. Involved in B cell homeostasis. Acts upstream of or within epidermal growth factor receptor signaling pathway and receptor recycling. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of GET complex. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human CAMLG (calcium modulating ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 23.2), CNS E18 (RPKM 22.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55770818..55780229)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55623005..55632416)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis
Title: Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
supports T cell survival and cell division downstream of T cell activation
Title: Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.
Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Title: Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.
Conditional deletion of CAML in CD19-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Title: Essential role for CAML in follicular B cell survival and homeostasis.
Loss of CAMLG protein failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis.
Title: CAML regulates Bim-dependent thymocyte death.
results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
Title: Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC maintenance.
Title: CAML loss causes anaphase failure and chromosome missegregation.
specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A) receptors
Title: Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors.
CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase p56(p56Lck) signaling.
Title: CAML is a p56Lck-interacting protein that is required for thymocyte development.
These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor (EGF) receptor signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF.
Title: CAML is required for efficient EGF receptor recycling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U21960 (e-PCR)
- UniSTS:125696

AI385748 (e-PCR)
- UniSTS:180539

Homology

Homologs of the Caml gene: The Caml gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 502 organisms have orthologs with human gene Caml
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of GET complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guided entry of tail-anchored proteins factor CAMLG

Names: calcium signal-modulating cyclophilin ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.