Format

Send to:

Choose Destination

CAMLG calcium modulating ligand [ Homo sapiens (human) ]

Gene ID: 819, updated on 5-Aug-2018
Official Symbol
CAMLGprovided by HGNC
Official Full Name
calcium modulating ligandprovided by HGNC
Primary source
HGNC:HGNC:1471
See related
Ensembl:ENSG00000164615 MIM:601118; Vega:OTTHUMG00000129116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAML; GET2
Summary
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 22.3), ovary (RPKM 21.6) and 25 other tissues See more
Orthologs
See CAMLG in Genome Data Viewer
Location:
5q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (134738480..134752160)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134074170..134087850)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene RNA, U6 small nuclear 1164, pseudogene Neighboring gene RNA, U6 small nuclear 757, pseudogene Neighboring gene DEAD-box helicase 46 Neighboring gene ribosomal protein L34 pseudogene 13 Neighboring gene chromosome 5 open reading frame 24

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC163197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
receptor recycling IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
Preferred Names
calcium signal-modulating cyclophilin ligand
Names
calcium-modulating cyclophilin ligand
cyclophilin B-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001745.3NP_001736.1  calcium signal-modulating cyclophilin ligand

    See identical proteins and their annotated locations for NP_001736.1

    Status: REVIEWED

    Source sequence(s)
    AC010301, BX111055, DA727548, U18242
    Consensus CDS
    CCDS4178.1
    UniProtKB/Swiss-Prot
    P49069
    Related
    ENSP00000297156.2, OTTHUMP00000159378, ENST00000297156.3, OTTHUMT00000251161
    Conserved Domains (1) summary
    pfam14963
    Location:23292
    CAML; Calcium signal-modulating cyclophilin ligand

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    134738480..134752160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center