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CCR1 C-C motif chemokine receptor 1 [ Homo sapiens (human) ]

Gene ID: 1230, updated on 5-Jul-2020

Summary

Official Symbol
CCR1provided by HGNC
Official Full Name
C-C motif chemokine receptor 1provided by HGNC
Primary source
HGNC:HGNC:1602
See related
Ensembl:ENSG00000163823 MIM:601159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues See more
Orthologs

Genomic context

See CCR1 in Genome Data Viewer
Location:
3p21.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46201711..46208313, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46243200..46249832, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding factor 2 pseudogene 2 Neighboring gene X-C motif chemokine receptor 1 Neighboring gene uncharacterized LOC105377067 Neighboring gene FLT1 pseudogene 1 Neighboring gene C-C motif chemokine receptor 3 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
Nef nef HIV-1 Nef induces variable levels of CCR1 downregulation in different cell types PubMed
Tat tat HIV-1 Tat protein modulates CCR1 and CCR3 mRNA expression in blood-brain barrier cultures, suggesting HIV-induced molecules can manipulate the surface receptor expression of the blood-brain barrier for their preferential entry into brain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine (C-C motif) ligand 5 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine (C-C motif) ligand 5 binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine (C-C motif) ligand 7 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine (C-C motif) ligand 7 binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
chemokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-C chemokine receptor type 1
Names
C-C CKR-1
CC-CKR-1
CCR-1
LD78 receptor
MIP-1alpha-R
RANTES receptor
RANTES-R
chemokine (C-C motif) receptor 1
macrophage inflammatory protein 1-alpha receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001295.3NP_001286.1  C-C chemokine receptor type 1

    See identical proteins and their annotated locations for NP_001286.1

    Status: REVIEWED

    Source sequence(s)
    AI089760, BC064991, BX337412, CK903574
    Consensus CDS
    CCDS2737.1
    UniProtKB/Swiss-Prot
    P32246
    UniProtKB/TrEMBL
    Q5U003
    Related
    ENSP00000296140.3, ENST00000296140.4
    Conserved Domains (1) summary
    cd15183
    Location:35312
    7tmA_CCR1; CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    46201711..46208313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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