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CCR1 C-C motif chemokine receptor 1 [ Homo sapiens (human) ]

Gene ID: 1230, updated on 2-Nov-2024

Summary

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Official Symbol
CCR1provided by HGNC
Official Full Name
C-C motif chemokine receptor 1provided by HGNC
Primary source
HGNC:HGNC:1602
See related
Ensembl:ENSG00000163823 MIM:601159; AllianceGenome:HGNC:1602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See CCR1 in Genome Data Viewer
Location:
3p21.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (46201711..46208313, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (46217573..46224175, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46243202..46249804, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FLT1 pseudogene 1 Neighboring gene uncharacterized LOC105377067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46211627-46212128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46212129-46212628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19795 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70326 Neighboring gene C-C motif chemokine receptor 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:46280932-46281488 Neighboring gene NANOG hESC enhancer GRCh37_chr3:46285885-46286429 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and regulation of CCR1 by airway smooth muscle cells in asthma. Joubert P, et al. J Immunol, 2008 Jan 15. PMID 18178867
  2. Mucosal CCR1 gene expression as a marker of molecular activity in Crohn's disease: preliminary data. Dobre M, et al. Rom J Morphol Embryol, 2017. PMID 29556615
  3. Reduced expression of the chemokine receptor CCR1 in human macrophages and U-937 cells in vitro infected with Leishmania infantum. Panaro MA, et al. Clin Exp Med, 2004 Apr. PMID 15103513
  4. Increased levels of CD4(+) and CD8(+) T cells expressing CCR1 in patients developing allograft dysfunction; a cohort study. Foroughi F, et al. Transpl Immunol, 2016 Sep. PMID 27234431
  5. CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. Conroy MJ, et al. Immunol Cell Biol, 2016 Jul. PMID 27046081

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterizing ligand-receptor interactions and unveiling the pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment of hepatocellular carcinoma.
    Title: Characterizing ligand-receptor interactions and unveiling the pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment of hepatocellular carcinoma.
  2. CCR1 mediates Muller cell activation and photoreceptor cell death in macular and retinal degeneration.
    Title: CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration.
  3. Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Galphai Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
    Title: Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
  4. The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.
    Title: The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.
  5. Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.
    Title: Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.
  6. Identification of ITGAX and CCR1 as potential biomarkers of atherosclerosis via Gene Set Enrichment Analysis.
    Title: Identification of ITGAX and CCR1 as potential biomarkers of atherosclerosis via Gene Set Enrichment Analysis.
  7. Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-kappaB pathway.
    Title: Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway.
  8. Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
    Title: Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
  9. CD14, CD163, and CCR1 are involved in heart and blood communication in ischemic cardiac diseases.
    Title: CD14, CD163, and CCR1 are involved in heart and blood communication in ischemic cardiac diseases.
  10. Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells <em>in vivo</em>.
    Title: Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies new susceptibility loci for Beh&amp;#x000e7;et's disease and epistasis between HLA-B*51 and ERAP1.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
Nef nef HIV-1 Nef induces variable levels of CCR1 downregulation in different cell types PubMed
Tat tat HIV-1 Tat protein modulates CCR1 and CCR3 mRNA expression in blood-brain barrier cultures, suggesting HIV-induced molecules can manipulate the surface receptor expression of the blood-brain barrier for their preferential entry into brain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chemokine (C-C motif) ligand 5 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemokine (C-C motif) ligand 5 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chemokine (C-C motif) ligand 7 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemokine (C-C motif) ligand 7 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-cell signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to wounding TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-C chemokine receptor type 1
Names
C-C CKR-1
CC-CKR-1
CCR-1
LD78 receptor
MIP-1alpha-R
RANTES receptor
RANTES-R
chemokine (C-C motif) receptor 1
macrophage inflammatory protein 1-alpha receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001295.3 → NP_001286.1  C-C chemokine receptor type 1

    See identical proteins and their annotated locations for NP_001286.1

    Status: REVIEWED

    Source sequence(s)
    AI089760, BC064991, BX337412, CK903574
    Consensus CDS
    CCDS2737.1
    UniProtKB/Swiss-Prot
    P32246, Q86VA9
    UniProtKB/TrEMBL
    A0A024R2P9, Q5U003
    Related
    ENSP00000296140.3, ENST00000296140.4
    Conserved Domains (1) summary
    cd15183
    Location:35 → 312
    7tmA_CCR1; CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    46201711..46208313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    46217573..46224175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32246.1 GenPept UniProtKB/Swiss-Prot:P32246

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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