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Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [ Mus musculus (house mouse) ]

Gene ID: 12290, updated on 8-Feb-2024

Summary

Official Symbol
Cacna1eprovided by MGI
Official Full Name
calcium channel, voltage-dependent, R type, alpha 1E subunitprovided by MGI
Primary source
MGI:MGI:106217
See related
Ensembl:ENSMUSG00000004110 AllianceGenome:MGI:106217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BII; Cach6; Cav2.3; Cchra1; alpha1E; Cacnl1a6; A430040I15
Summary
This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]
Expression
Biased expression in frontal lobe adult (RPKM 6.4), cortex adult (RPKM 6.1) and 8 other tissues See more
Orthologs
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Genomic context

See Cacna1e in Genome Data Viewer
Location:
1 G3; 1 66.14 cM
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (154266552..154760374, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (154390806..154884785, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930532M18 gene Neighboring gene predicted gene, 30465 Neighboring gene golgi SNAP receptor complex member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:156464654-156464955 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156493503-156493803 Neighboring gene STARR-seq mESC enhancer starr_02714 Neighboring gene STARR-seq mESC enhancer starr_02715 Neighboring gene STARR-seq mESC enhancer starr_02716 Neighboring gene STARR-positive B cell enhancer ABC_E4359 Neighboring gene STARR-positive B cell enhancer ABC_E2014 Neighboring gene predicted gene, 51649 Neighboring gene STARR-seq mESC enhancer starr_02717 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156696300-156696601 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156698156-156698457 Neighboring gene STARR-seq mESC enhancer starr_02718 Neighboring gene predicted gene, 30521 Neighboring gene predicted gene, 41976 Neighboring gene predicted gene, 30602

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of somatostatin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated calcium channel complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated calcium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
voltage-dependent R-type calcium channel subunit alpha-1E
Names
brain calcium channel II
calcium channel, L type, alpha-1 polypeptide
calcium channel, voltage-dependent, L type, alpha 1E subunit
voltage-gated calcium channel subunit alpha Cav2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009782.3NP_033912.2  voltage-dependent R-type calcium channel subunit alpha-1E

    Status: REVIEWED

    Source sequence(s)
    AC099707, AC101727, AC122040
    Consensus CDS
    CCDS78710.1
    UniProtKB/TrEMBL
    A0A087WS83, B2RWX7
    Related
    ENSMUSP00000140937.2, ENSMUST00000187541.7
    Conserved Domains (5) summary
    pfam00520
    Location:14981737
    Ion_trans; Ion transport protein
    pfam05439
    Location:341374
    JTB; Jumping translocation breakpoint protein (JTB)
    pfam07816
    Location:20132117
    DUF1645; Protein of unknown function (DUF1645)
    pfam08763
    Location:18101884
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17451808
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    154266552..154760374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243929.1XP_030099789.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21682243
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. XM_017312578.3XP_017168067.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21682243
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  3. XM_017312848.1XP_017168337.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:14801737
    Ion_trans; Ion transport protein
    pfam08763
    Location:18101883
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:20222097
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:17461799
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  4. XM_017312712.1XP_017168201.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X8

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:15961853
    Ion_trans; Ion transport protein
    pfam08763
    Location:19261999
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21382213
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18621915
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  5. XM_017312660.1XP_017168149.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X6

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16071864
    Ion_trans; Ion transport protein
    pfam08763
    Location:19372010
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21492224
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18731926
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  6. XM_017312628.1XP_017168117.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X4

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16221879
    Ion_trans; Ion transport protein
    pfam08763
    Location:19522025
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21642239
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18881941
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  7. XM_017312642.1XP_017168131.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X5

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16221879
    Ion_trans; Ion transport protein
    pfam08763
    Location:19522025
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21642239
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18881941
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  8. XM_017312619.1XP_017168108.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X3

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21642239
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  9. XM_017312730.1XP_017168219.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X9

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21252200
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  10. XM_017312613.1XP_017168102.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21682243
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  11. XM_030243926.1XP_030099786.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21682243
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  12. XM_011247909.4XP_011246211.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

    See identical proteins and their annotated locations for XP_011246211.1

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21682243
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  13. XM_011247916.4XP_011246218.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:14801737
    Ion_trans; Ion transport protein
    pfam08763
    Location:18101883
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:20222097
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:17461799
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  14. XM_030244154.2XP_030100014.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X15

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam17069
    Location:19662090
    RSRP; Arginine/Serine-Rich protein 1
    pfam00520
    Location:14311688
    Ion_trans; Ion transport protein
    pfam08763
    Location:17611834
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:16971750
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  15. XM_017312745.2XP_017168234.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X10

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21212196
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  16. XM_017312824.2XP_017168313.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X13

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16071864
    Ion_trans; Ion transport protein
    pfam08763
    Location:19372010
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21022177
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18731926
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  17. XM_017312766.2XP_017168255.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X11

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21212196
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  18. XM_017312795.2XP_017168284.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X12

    UniProtKB/TrEMBL
    B2RWX7
    Conserved Domains (4) summary
    pfam00520
    Location:16071864
    Ion_trans; Ion transport protein
    pfam08763
    Location:19372010
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21022177
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18731926
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  19. XM_017312682.2XP_017168171.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X7

    UniProtKB/TrEMBL
    B2RWX7
    Related
    ENSMUSP00000148507.2, ENSMUST00000211821.2
    Conserved Domains (4) summary
    pfam00520
    Location:16071864
    Ion_trans; Ion transport protein
    pfam08763
    Location:19372010
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10500
    Location:21452220
    SR-25; Nuclear RNA-splicing-associated protein
    pfam16905
    Location:18731926
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  20. XM_036155941.1XP_036011834.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X16

    UniProtKB/Swiss-Prot
    Q61290
    Conserved Domains (3) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein
    pfam08763
    Location:19562029
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18921945
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  21. XM_006529105.5XP_006529168.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X17

    Conserved Domains (1) summary
    pfam00520
    Location:16261883
    Ion_trans; Ion transport protein