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IFI27L1 interferon alpha inducible protein 27 like 1 [ Homo sapiens (human) ]

Gene ID: 122509, updated on 11-Jun-2021

Summary

Official Symbol
IFI27L1provided by HGNC
Official Full Name
interferon alpha inducible protein 27 like 1provided by HGNC
Primary source
HGNC:HGNC:19754
See related
Ensembl:ENSG00000165948 MIM:611320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM14B; ISG12C
Expression
Broad expression in testis (RPKM 8.5), adrenal (RPKM 3.1) and 23 other tissues See more
Orthologs
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Genomic context

See IFI27L1 in Genome Data Viewer
Location:
14q32.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94081308..94102710)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94547656..94569055)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4126 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene DEAD-box helicase 24 Neighboring gene interferon alpha inducible protein 27 Neighboring gene interferon alpha inducible protein 27 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon alpha-inducible protein 27-like protein 1
Names
ISG12(c) protein
family with sequence similarity 14, member B
interferon-stimulated gene 12c protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145249.3NP_660292.1  interferon alpha-inducible protein 27-like protein 1

    See identical proteins and their annotated locations for NP_660292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL079302, BC015423, DA693965
    Consensus CDS
    CCDS9919.1
    UniProtKB/Swiss-Prot
    Q96BM0
    Related
    ENSP00000376824.3, ENST00000393115.7
    Conserved Domains (1) summary
    pfam06140
    Location:3196
    Ifi-6-16; Interferon-induced 6-16 family
  2. NM_206949.3NP_996832.1  interferon alpha-inducible protein 27-like protein 1

    See identical proteins and their annotated locations for NP_996832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BN000225, BU739372, DA693965
    Consensus CDS
    CCDS9919.1
    UniProtKB/Swiss-Prot
    Q96BM0
    Related
    ENSP00000451851.1, ENST00000555523.6
    Conserved Domains (1) summary
    pfam06140
    Location:3196
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94081308..94102710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536405.3XP_011534707.1  interferon alpha-inducible protein 27-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011534707.1

    UniProtKB/Swiss-Prot
    Q96BM0
    Conserved Domains (1) summary
    pfam06140
    Location:3196
    Ifi-6-16; Interferon-induced 6-16 family
  2. XM_011536407.2XP_011534709.1  interferon alpha-inducible protein 27-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011534709.1

    Related
    ENSP00000452226.1, ENST00000554166.5
    Conserved Domains (1) summary
    pfam06140
    Location:3095
    Ifi-6-16; Interferon-induced 6-16 family
  3. XM_011536406.2XP_011534708.1  interferon alpha-inducible protein 27-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011534708.1

    Related
    ENSP00000451608.1, ENST00000555341.5
    Conserved Domains (1) summary
    pfam06140
    Location:3095
    Ifi-6-16; Interferon-induced 6-16 family
  4. XM_017020963.2XP_016876452.1  interferon alpha-inducible protein 27-like protein 1 isoform X4

    Related
    ENSP00000450620.1, ENST00000554562.1
  5. XM_017020962.2XP_016876451.1  interferon alpha-inducible protein 27-like protein 1 isoform X3

  6. XM_017020961.1XP_016876450.1  interferon alpha-inducible protein 27-like protein 1 isoform X2

    Related
    ENSP00000451043.1, ENST00000553664.1
  7. XM_005267314.5XP_005267371.1  interferon alpha-inducible protein 27-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267371.1

    Conserved Domains (1) summary
    pfam06140
    Location:56121
    Ifi-6-16; Interferon-induced 6-16 family

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1195872..1217271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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