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CSNK1A1L casein kinase 1 alpha 1 like [ Homo sapiens (human) ]

Gene ID: 122011, updated on 3-Nov-2024

Summary

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Official Symbol
CSNK1A1Lprovided by HGNC
Official Full Name
casein kinase 1 alpha 1 likeprovided by HGNC
Primary source
HGNC:HGNC:20289
See related
Ensembl:ENSG00000180138 AllianceGenome:HGNC:20289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK1
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CSNK1A1L in Genome Data Viewer
Location:
13q13.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (37103259..37105664, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (36322441..36324846, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37677396..37679801, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7594 Neighboring gene exosome component 8 Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5271 Neighboring gene RN7SK pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:37772677-37773347 Neighboring gene ribosomal protein S12 pseudogene 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells. Darnay BG, et al. J Biol Chem, 1994 Aug 5. PMID 8051045
  2. Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src. Hoang LN, et al. Cell Signal, 2023 Aug. PMID 37257767
  3. The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. Streichert T, et al. Biochem Biophys Res Commun, 2001 Nov 23. PMID 11708798
  4. Peli1 Modulates the Subcellular Localization and Activity of Mdmx. Li D, et al. Cancer Res, 2018 Jun 1. PMID 29523541, Free PMC Article
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Wu JH, et al. Circ Cardiovasc Genet, 2013 Apr. PMID 23362303, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src.
    Title: Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform alpha-like
Names
CKI-alpha-like
casein kinase I alpha S-like
NP_660204.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145203.6 → NP_660204.2  casein kinase I isoform alpha-like

    See identical proteins and their annotated locations for NP_660204.2

    Status: VALIDATED

    Source sequence(s)
    AL391383, BC028723
    Consensus CDS
    CCDS9363.1
    UniProtKB/Swiss-Prot
    Q5T2N2, Q8N752
    Related
    ENSP00000369126.3, ENST00000379800.4
    Conserved Domains (2) summary
    COG0515
    Location:16 → 239
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    37103259..37105664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    36322441..36324846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N752.2 GenPept UniProtKB/Swiss-Prot:Q8N752

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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