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Zfp36l2 zinc finger protein 36, C3H type-like 2 [ Mus musculus (house mouse) ]

Gene ID: 12193, updated on 3-Jun-2024

Summary

Official Symbol
Zfp36l2provided by MGI
Official Full Name
zinc finger protein 36, C3H type-like 2provided by MGI
Primary source
MGI:MGI:107945
See related
Ensembl:ENSMUSG00000045817 AllianceGenome:MGI:107945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brf2; ERF2; Tis11d
Summary
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including hemopoiesis; negative regulation of cell differentiation; and positive regulation of mRNA catabolic process. Acts upstream of or within hemopoiesis and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 134.5), ovary adult (RPKM 123.4) and 23 other tissues See more
Orthologs
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Genomic context

See Zfp36l2 in Genome Data Viewer
Location:
17 E4; 17 55.02 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84491352..84495375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84183924..84187947, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:84580066-84580358 Neighboring gene STARR-positive B cell enhancer ABC_E11651 Neighboring gene VISTA enhancer mm1108 Neighboring gene predicted gene, 41640 Neighboring gene STARR-positive B cell enhancer mm9_chr17:84587213-84587514 Neighboring gene predicted gene, 36279 Neighboring gene thyroid adenoma associated Neighboring gene predicted gene, 24492

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mRNA decay activator protein ZFP36L2
Names
TPA-induced sequence 11d
ZFP36-like 2
butyrate response factor 2
zinc finger protein 36, C3H1 type-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001806.2NP_001001806.1  mRNA decay activator protein ZFP36L2

    See identical proteins and their annotated locations for NP_001001806.1

    Status: VALIDATED

    Source sequence(s)
    AC132455, BB656287
    Consensus CDS
    CCDS28998.1
    UniProtKB/Swiss-Prot
    B9EIF6, P23949, Q3TCE3, Q3TU59
    Related
    ENSMUSP00000050820.7, ENSMUST00000060366.7
    Conserved Domains (2) summary
    pfam00642
    Location:156181
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:3133
    Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84491352..84495375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007565.3: Suppressed sequence

    Description
    NM_007565.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.