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ZFP36L2 ZFP36 ring finger protein like 2 [ Homo sapiens (human) ]

Gene ID: 678, updated on 21-Dec-2019

Summary

Official Symbol
ZFP36L2provided by HGNC
Official Full Name
ZFP36 ring finger protein like 2provided by HGNC
Primary source
HGNC:HGNC:1108
See related
Ensembl:ENSG00000152518 MIM:612053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRF2; ERF2; ERF-2; TIS11D; RNF162C
Summary
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues See more
Orthologs

Genomic context

See ZFP36L2 in Genome Data Viewer
Location:
2p21
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (43222402..43226606, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (43449541..43453745, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.1723 Neighboring gene VISTA enhancer hs1909 Neighboring gene uncharacterized LOC107985877 Neighboring gene long intergenic non-protein coding RNA 1126 Neighboring gene THADA armadillo repeat containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA binding HDA PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
3'-UTR-mediated mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
definitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mitotic cell cycle phase transition ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
somatic stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mRNA decay activator protein ZFP36L2
Names
EGF-response factor 2
TPA-induced sequence 11d
ZFP36-like 2
butyrate response factor 2
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 2
zinc finger protein 36, C3H1 type-like 2
zinc finger protein, C3H type, 36-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006887.5NP_008818.3  mRNA decay activator protein ZFP36L2

    See identical proteins and their annotated locations for NP_008818.3

    Status: REVIEWED

    Source sequence(s)
    AC010883, N67537
    Consensus CDS
    CCDS1811.1
    UniProtKB/Swiss-Prot
    P47974
    Related
    ENSP00000282388.3, ENST00000282388.4
    Conserved Domains (2) summary
    pfam00642
    Location:154179
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:3131
    Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    43222402..43226606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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