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Zfp36l1 zinc finger protein 36, C3H type-like 1 [ Mus musculus (house mouse) ]

Gene ID: 12192, updated on 6-Dec-2022

Summary

Official Symbol
Zfp36l1provided by MGI
Official Full Name
zinc finger protein 36, C3H type-like 1provided by MGI
Primary source
MGI:MGI:107946
See related
Ensembl:ENSMUSG00000021127 AllianceGenome:MGI:107946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brf1; ERF1; cMG1; Berg36; TIS11b; D530020L18Rik
Summary
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to organonitrogen compound; and intracellular signal transduction. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and proepicardium development. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and spinal cord. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 144.4), ovary adult (RPKM 112.7) and 25 other tissues See more
Orthologs
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Genomic context

See Zfp36l1 in Genome Data Viewer
Location:
12; 12 C3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80154534..80159787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80107760..80113013, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36660 Neighboring gene predicted gene, 36834 Neighboring gene VISTA enhancer mm1469 Neighboring gene RIKEN cDNA 2310015A10 gene Neighboring gene actinin, alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to peptide hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to peptide hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to raffinose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to salt stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chorio-allantoic fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mesendoderm development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intracellular mRNA localization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proepicardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spongiotrophoblast layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mRNA decay activator protein ZFP36L1
Names
TPA-induced sequence 11b
ZFP36-like 1
butyrate response factor 1
zinc finger protein 36, C3H1 type-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007564.5NP_031590.1  mRNA decay activator protein ZFP36L1

    See identical proteins and their annotated locations for NP_031590.1

    Status: PROVISIONAL

    Source sequence(s)
    AC108401
    Consensus CDS
    CCDS26010.1
    UniProtKB/Swiss-Prot
    P23950
    UniProtKB/TrEMBL
    A0A6P5QW04, Q543H2
    Related
    ENSMUSP00000021552.2, ENSMUST00000021552.3
    Conserved Domains (2) summary
    pfam04553
    Location:399
    Tis11B_N; Tis11B like protein, N terminus
    cl11592
    Location:115177
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80154534..80159787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)