Zfp36l1 zinc finger protein 36, C3H type-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp36l1provided by MGI
Official Full Name: zinc finger protein 36, C3H type-like 1provided by MGI
Primary source: MGI:MGI:107946
See related: Ensembl:ENSMUSG00000021127 AllianceGenome:MGI:107946
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brf1; ERF1; cMG1; Berg36; TIS11b; D530020L18Rik
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to cAMP; and cellular response to raffinose. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and post-transcriptional regulation of gene expression. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 144.4), ovary adult (RPKM 112.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 36.46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (80154534..80159787, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (80107760..80113013, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.
Title: ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Title: Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.
Title: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.
Study shows that the ZFP36 family member, ZFP36L1, is specifically upregulated in osteoarthritis (OA) chondrocytes and OA cartilage of humans and mice. ZFP36L1 regulates the mRNAs encoding two members of the HSP70 family that appear to exert protective effects on OA pathogenesis by inhibiting chondrocyte apoptosis.
Title: RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.
ZFP36L1 protein is expressed in satellite cells. ZFP36L1 and ZFP36L2 act redundantly in myogenesis.
Title: The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.
the ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis.
Title: RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.
The Zfp36l1 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control.
Title: The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.
Our data indicated that ZFP36L1 could act as an enhancer of osteoblastic differentiation but a repressor of adipogenic differentiation, supporting the notion that decreased ZFP36L1 expression in bone marrow stem cells might contribute to aging-related bone loss.
Title: Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells.
ZFP36L1 is the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce e follicular B cell phenotype.
Title: Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
Title: RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Brf1 (e-PCR), detects polymorphism
- UniSTS:141192

G15966 (e-PCR)
- UniSTS:52394

AW742437 (e-PCR)
- UniSTS:208830

AW743212 (e-PCR)
- UniSTS:207614

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to peptide hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to peptide hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to raffinose	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to salt stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chorio-allantoic fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesendoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular mRNA localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proepicardium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spongiotrophoblast layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mRNA decay activator protein ZFP36L1

Names: TPA-induced sequence 11b; ZFP36-like 1; butyrate response factor 1; zinc finger protein 36, C3H1 type-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007564.5 → NP_031590.1 mRNA decay activator protein ZFP36L1

See identical proteins and their annotated locations for NP_031590.1

Status: PROVISIONAL

Source sequence(s)

AC108401

Consensus CDS

CCDS26010.1

UniProtKB/Swiss-Prot

P23950

UniProtKB/TrEMBL

Q543H2, Q91YI7

Related

ENSMUSP00000021552.2, ENSMUST00000021552.3

Conserved Domains (2) summary

pfam04553
Location:3 → 99

Tis11B_N; Tis11B like protein, N terminus

cl11592
Location:115 → 177

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)