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ZFP36L1 ZFP36 ring finger protein like 1 [ Homo sapiens (human) ]

Gene ID: 677, updated on 8-Dec-2018

Summary

Official Symbol
ZFP36L1provided by HGNC
Official Full Name
ZFP36 ring finger protein like 1provided by HGNC
Primary source
HGNC:HGNC:1107
See related
Ensembl:ENSG00000185650 MIM:601064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B
Summary
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues See more
Orthologs

Genomic context

See ZFP36L1 in Genome Data Viewer
Location:
14q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (68787655..68796243, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69254372..69263184, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984709 Neighboring gene HNF1 motif-containing MPRA enhancer 48 Neighboring gene mago homolog 3, pseudogene Neighboring gene basic leucine zipper nuclear factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA binding HDA PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to peptide hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to raffinose ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to salt stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
chorio-allantoic fusion IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesendoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle phase transition ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
proepicardium development IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
spongiotrophoblast layer development IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA decay activator protein ZFP36L1
Names
EGF-response factor 1
TPA-induced sequence 11b
ZFP36-like 1
butyrate response factor 1
early response factor Berg36
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H1 type-like 1
zinc finger protein, C3H type, 36-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244698.1NP_001231627.1  mRNA decay activator protein ZFP36L1 isoform 1

    See identical proteins and their annotated locations for NP_001231627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 3' end, and has a shorter 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI809725, AK024202, AL132986, BC018340, BQ004874, BQ894292, DA876968, DR423896
    Consensus CDS
    CCDS9791.1
    UniProtKB/Swiss-Prot
    Q07352
    UniProtKB/TrEMBL
    A0A024R658, B3KNA8
    Related
    ENSP00000337386.3, ENST00000336440.3
    Conserved Domains (2) summary
    pfam04553
    Location:399
    Tis11B_N; Tis11B like protein, N terminus
    cl11592
    Location:115177
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  2. NM_001244701.1NP_001231630.1  mRNA decay activator protein ZFP36L1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon at the 5' end compared to variant 1, that introduces an in-frame upstream AUG, translation from which results in an isoform (2) with a longer N-terminus compared to isoform 1.
    Source sequence(s)
    BC018340, BM712842, BP353132, BQ004874, BQ894292, DA633985, DR423896, FY210721
    UniProtKB/Swiss-Prot
    Q07352
    Conserved Domains (2) summary
    pfam00642
    Location:184209
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:72168
    Tis11B_N; Tis11B like protein, N terminus
  3. NM_004926.3NP_004917.2  mRNA decay activator protein ZFP36L1 isoform 1

    See identical proteins and their annotated locations for NP_004917.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI809725, AK024202, AL132986, BC018340, BM712842, BQ004874, BQ894292, DA876968, DR423896
    Consensus CDS
    CCDS9791.1
    UniProtKB/Swiss-Prot
    Q07352
    UniProtKB/TrEMBL
    A0A024R658, B3KNA8
    Related
    ENSP00000388402.2, ENST00000439696.2
    Conserved Domains (2) summary
    pfam04553
    Location:399
    Tis11B_N; Tis11B like protein, N terminus
    cl11592
    Location:115177
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    68787655..68796243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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