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Bnip2 BCL2/adenovirus E1B interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 12175, updated on 30-Apr-2024

Summary

Official Symbol
Bnip2provided by MGI
Official Full Name
BCL2/adenovirus E1B interacting protein 2provided by MGI
Primary source
MGI:MGI:109327
See related
Ensembl:ENSMUSG00000011958 AllianceGenome:MGI:109327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nip21; BNIP2beta; 5730523P12Rik
Summary
Acts upstream of or within several processes, including blastocyst development; centrosome cycle; and positive regulation of intracellular signal transduction. Located in centriole and spindle pole centrosome. Orthologous to human BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 17.0), CNS E11.5 (RPKM 12.5) and 26 other tissues See more
Orthologs
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Genomic context

See Bnip2 in Genome Data Viewer
Location:
9 D; 9 39.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69896660..69918941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (69989438..70011659)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24527 Neighboring gene predicted gene, 39368 Neighboring gene predicted gene, 31587 Neighboring gene STARR-positive B cell enhancer ABC_E10561 Neighboring gene STARR-positive B cell enhancer ABC_E6762 Neighboring gene STARR-seq mESC enhancer starr_24528 Neighboring gene general transcription factor II A, 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Names
BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta
BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2
BCL2/adenovirus E1B interacting protein 1, NIP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008238.3NP_001008239.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform alpha

    See identical proteins and their annotated locations for NP_001008239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (alpha) encodes isoform alpha.
    Source sequence(s)
    AC137108
    Consensus CDS
    CCDS23318.1
    UniProtKB/TrEMBL
    Q91VL0, Q9D632
    Related
    ENSMUSP00000082513.7, ENSMUST00000085393.13
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  2. NM_001374750.1NP_001361679.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC137108, AK014659
    Consensus CDS
    CCDS90612.1
    UniProtKB/TrEMBL
    G5E8U9, Q9D632
    Related
    ENSMUSP00000113466.2, ENSMUST00000117450.8
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:50163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  3. NM_016787.4NP_058067.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform beta

    See identical proteins and their annotated locations for NP_058067.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (beta) uses an alternate in-frame exon in the 3' coding region compared to variant alpha. It encodes isoform beta which is longer than isoform alpha.
    Source sequence(s)
    AC137108, AK054288
    Consensus CDS
    CCDS23319.1
    UniProtKB/Swiss-Prot
    O54940, Q8K4H0
    UniProtKB/TrEMBL
    Q9D632
    Related
    ENSMUSP00000034754.6, ENSMUST00000034754.12
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69896660..69918941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510791.5XP_006510854.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    Q9D632
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:50163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  2. XM_006510793.5XP_006510856.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    Q9D632
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:50163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  3. XM_036154575.1XP_036010468.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd00170
    Location:16159
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  4. XM_036154578.1XP_036010471.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X4

    Conserved Domains (1) summary
    cd00170
    Location:16159
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  5. XM_036154576.1XP_036010469.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd00170
    Location:16159
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  6. XM_036154577.1XP_036010470.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd00170
    Location:16159
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...