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BNIP2 BCL2 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 663, updated on 22-Aug-2021

Summary

Official Symbol
BNIP2provided by HGNC
Official Full Name
BCL2 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:1083
See related
Ensembl:ENSG00000140299 MIM:603292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP2; BNIP-2
Summary
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 22.4), fat (RPKM 13.5) and 24 other tissues See more
Orthologs
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Genomic context

See BNIP2 in Genome Data Viewer
Location:
15q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (59659146..59689320, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59951345..59981519, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene general transcription factor IIA subunit 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6 Neighboring gene uncharacterized LOC107984803

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within apoptotic process IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxygen-glucose deprivation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Names
BCL2/adenovirus E1B 19kDa interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029765.2 RefSeqGene

    Range
    5124..35298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320674.2NP_001307603.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC092755
  2. NM_001320675.4NP_001307604.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC092755
    Consensus CDS
    CCDS81889.1
    Related
    ENSP00000412767.3, ENST00000415213.7
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  3. NM_001368057.1NP_001354986.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092755
  4. NM_001368058.1NP_001354987.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC092755
  5. NM_001368059.1NP_001354988.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC092755
  6. NM_001368060.1NP_001354989.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC092755
  7. NM_001368061.1NP_001354990.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC092755
  8. NM_004330.4NP_004321.3  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092755
    Consensus CDS
    CCDS10174.2
    Related
    ENSP00000475320.1, ENST00000607373.6
    Conserved Domains (2) summary
    cd00170
    Location:147290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    59659146..59689320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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