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Cspg4 chondroitin sulfate proteoglycan 4 [ Mus musculus (house mouse) ]

Gene ID: 121021, updated on 2-Apr-2024

Summary

Official Symbol
Cspg4provided by MGI
Official Full Name
chondroitin sulfate proteoglycan 4provided by MGI
Primary source
MGI:MGI:2153093
See related
Ensembl:ENSMUSG00000032911 AllianceGenome:MGI:2153093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AN2; NG2; Cspg4a; 4732461B14Rik
Summary
Enables coreceptor activity. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; and ruffle assembly. Located in plasma membrane and ruffle. Is expressed in several structures, including brain; jaw; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 17.6), mammary gland adult (RPKM 12.2) and 20 other tissues See more
Orthologs
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Genomic context

Location:
9 B; 9 30.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56772388..56807154)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56865104..56899870)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene predicted gene, 53525 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33 Neighboring gene predicted gene, 19936

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chondroitin sulfate proteoglycan 4
Names
AN2 proteoglycan
AN2/NG2 proteoglycan
chondroitin sulfate proteoglycan NG2
nerve/glial antigen 2
proteoglycan AN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139001.2NP_620570.2  chondroitin sulfate proteoglycan 4 precursor

    See identical proteins and their annotated locations for NP_620570.2

    Status: VALIDATED

    Source sequence(s)
    AC126257, AF352400, AK052394, AK140986, AK220559
    Consensus CDS
    CCDS23211.1
    UniProtKB/Swiss-Prot
    G5E892, Q5DTG1, Q8BPI8, Q8CE79, Q8VHY0
    Related
    ENSMUSP00000038909.6, ENSMUST00000035661.7
    Conserved Domains (3) summary
    cd00110
    Location:204362
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam16184
    Location:14251568
    Cadherin_3; Cadherin-like
    cl22861
    Location:55182
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56772388..56807154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)