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CSPG4 chondroitin sulfate proteoglycan 4 [ Homo sapiens (human) ]

Gene ID: 1464, updated on 27-Nov-2024

Summary

Official Symbol
CSPG4provided by HGNC
Official Full Name
chondroitin sulfate proteoglycan 4provided by HGNC
Primary source
HGNC:HGNC:2466
See related
Ensembl:ENSG00000173546 MIM:601172; AllianceGenome:HGNC:2466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NG2; MCSP; MCSPG; MSK16; CSPG4A; HMW-MAA; MEL-CSPG
Summary
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 18.8), placenta (RPKM 10.9) and 19 other tissues See more
Orthologs
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Genomic context

See CSPG4 in Genome Data Viewer
Location:
15q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75674322..75713466, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73545032..73584178, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75966663..76005189, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75940037-75940728 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75943426-75944362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945327-75945879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945880-75946431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949231-75949732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949733-75950232 Neighboring gene sorting nexin 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75952205-75952778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75953927-75954500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75966659-75967446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75974798-75975642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75978522-75979027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75979028-75979532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75985202-75985952 Neighboring gene Sharpr-MPRA regulatory region 4583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75989701-75990450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75990451-75991198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75993083-75993582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75993590-75994515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76019661-76020161 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76023672-76024603 Neighboring gene dynamin 1 pseudogene 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76028296-76028816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9864 Neighboring gene peptidylprolyl isomerase A pseudogene 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in substrate-dependent cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chondroitin sulfate proteoglycan 4
Names
chondroitin sulfate proteoglycan 4 (melanoma-associated)
chondroitin sulfate proteoglycan NG2
melanoma chondroitin sulfate proteoglycan
melanoma-associated chondroitin sulfate proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001897.5NP_001888.2  chondroitin sulfate proteoglycan 4 precursor

    See identical proteins and their annotated locations for NP_001888.2

    Status: REVIEWED

    Source sequence(s)
    AY359468, BP363063, BQ679485, CA428796, CA438367, X96753
    Consensus CDS
    CCDS10284.1
    UniProtKB/Swiss-Prot
    D3DW77, Q6UVK1, Q92675
    Related
    ENSP00000312506.5, ENST00000308508.5
    Conserved Domains (2) summary
    cd00110
    Location:203361
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam16184
    Location:14201563
    Cadherin_3; Cadherin-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    75674322..75713466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432196.1XP_047288152.1  chondroitin sulfate proteoglycan 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    73545032..73584178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377370.1XP_054233345.1  chondroitin sulfate proteoglycan 4 isoform X1