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CLPS colipase [ Homo sapiens (human) ]

Gene ID: 1208, updated on 21-Dec-2019

Summary

Official Symbol
CLPSprovided by HGNC
Official Full Name
colipaseprovided by HGNC
Primary source
HGNC:HGNC:2085
See related
Ensembl:ENSG00000137392 MIM:120105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Restricted expression toward pancreas (RPKM 17741.6) See more
Orthologs

Genomic context

See CLPS in Genome Data Viewer
Location:
6p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (35794982..35797344, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35762759..35765121, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene colipase like 2 Neighboring gene colipase like 1 Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene SRSF protein kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates pancreatic colipase in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid digestion TAS
Traceable Author Statement
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to food IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
colipase
Names
colipase, pancreatic
pancreatic colipase preproprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252597.2NP_001239526.1  colipase isoform 2

    See identical proteins and their annotated locations for NP_001239526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. Translation of variant 2 begins in the alternate exon, and the resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BI439786, BP322637, BP324927, BQ271978
    Consensus CDS
    CCDS75437.1
    UniProtKB/TrEMBL
    A0A087WZW1
    Related
    ENSP00000482919.1, ENST00000622413.2
    Conserved Domains (1) summary
    smart00023
    Location:1598
    COLIPASE; Colipase
  2. NM_001252598.1NP_001239527.1  colipase isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001239527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BP321569, BP324927, BQ271978
    Consensus CDS
    CCDS75438.1
    UniProtKB/TrEMBL
    A0A087X0Q7
    Related
    ENSP00000483589.1, ENST00000616014.3
    Conserved Domains (1) summary
    smart00023
    Location:1871
    COLIPASE; Colipase
  3. NM_001832.4NP_001823.1  colipase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BP324927
    Consensus CDS
    CCDS4811.1
    UniProtKB/Swiss-Prot
    P04118
    Related
    ENSP00000259938.2, ENST00000259938.7
    Conserved Domains (1) summary
    smart00023
    Location:18112
    COLIPASE; Colipase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    35794982..35797344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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