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Bcap29 B cell receptor associated protein 29 [ Mus musculus (house mouse) ]

Gene ID: 12033, updated on 2-Nov-2024

Summary

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Official Symbol
Bcap29provided by MGI
Official Full Name
B cell receptor associated protein 29provided by MGI
Primary source
MGI:MGI:101917
See related
Ensembl:ENSMUSG00000020650 AllianceGenome:MGI:101917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bap29
Summary
Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including ganglia; gut; submandibular gland primordium; telencephalon ventricular layer; and vibrissa. Orthologous to human BCAP29 (B cell receptor associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 21.6), cortex adult (RPKM 9.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Bcap29 in Genome Data Viewer
Location:
12 A2- A3; 12 13.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31645353..31684657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31595354..31634658, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Casitas B-lineage lymphoma-like 1 Neighboring gene predicted gene, 40362 Neighboring gene solute carrier family 26, member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32339618-32339801 Neighboring gene STARR-seq mESC enhancer starr_31859 Neighboring gene dihydrouridine synthase 4 like Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two new proteins preferentially associated with membrane immunoglobulin D. Kim KM, et al. EMBO J, 1994 Aug 15. PMID 8070407, Free PMC Article
  2. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. Terashima M, et al. EMBO J, 1994 Aug 15. PMID 8070406, Free PMC Article
  3. Bap29/31 influences the intracellular traffic of MHC class I molecules. Paquet ME, et al. J Immunol, 2004 Jun 15. PMID 15187134
  4. A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Schamel WW, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12886015, Free PMC Article
  5. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.
    Title: A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.
  2. results are consistent with the view that class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules
    Title: Bap29/31 influences the intracellular traffic of MHC class I molecules.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
B-cell receptor-associated protein 29
Names
BCR-associated protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164090.1 → NP_001157562.1  B-cell receptor-associated protein 29

    See identical proteins and their annotated locations for NP_001157562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC119950
    Consensus CDS
    CCDS25864.1
    UniProtKB/Swiss-Prot
    Q61334
    UniProtKB/TrEMBL
    Q542A1
    Related
    ENSMUSP00000137260.2, ENSMUST00000177962.9
    Conserved Domains (1) summary
    pfam05529
    Location:1 → 219
    Bap31; B-cell receptor-associated protein 31-like

  2. NM_007530.3 → NP_031556.1  B-cell receptor-associated protein 29

    See identical proteins and their annotated locations for NP_031556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC119950
    Consensus CDS
    CCDS25864.1
    UniProtKB/Swiss-Prot
    Q61334
    UniProtKB/TrEMBL
    Q542A1
    Related
    ENSMUSP00000020979.8, ENSMUST00000020979.9
    Conserved Domains (1) summary
    pfam05529
    Location:1 → 219
    Bap31; B-cell receptor-associated protein 31-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31645353..31684657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61334.1 GenPept UniProtKB/Swiss-Prot:Q61334

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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