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Bag1 BCL2-associated athanogene 1 [ Mus musculus (house mouse) ]

Gene ID: 12017, updated on 8-Feb-2024

Summary

Official Symbol
Bag1provided by MGI
Official Full Name
BCL2-associated athanogene 1provided by MGI
Primary source
MGI:MGI:108047
See related
Ensembl:ENSMUSG00000028416 AllianceGenome:MGI:108047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAG-1; Rap46
Summary
The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach adult (RPKM 201.2), adrenal adult (RPKM 182.6) and 28 other tissues See more
Orthologs
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Genomic context

See Bag1 in Genome Data Viewer
Location:
4 A5; 4 20.67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40936398..40948294, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40936398..40948294, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 2B pseudogene Neighboring gene serine peptidase inhibitor, Kazal type 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:40895401-40895689 Neighboring gene charged multivesicular body protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E3485 Neighboring gene predicted gene, 52692 Neighboring gene nuclear transcription factor, X-box binding 1 Neighboring gene microRNA 3094

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BAG family molecular chaperone regulator 1
Names
Bcl-2-binding protein
bcl-2-associated athanogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171739.1NP_001165210.1  BAG family molecular chaperone regulator 1 isoform 1S

    See identical proteins and their annotated locations for NP_001165210.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The shorter isoform (1S) is represented in this RefSeq.
    Source sequence(s)
    AK009149, AK013611, BQ031093, CX225744
    Consensus CDS
    CCDS51139.1
    UniProtKB/Swiss-Prot
    Q60739
    UniProtKB/TrEMBL
    Q9CUY1
    Related
    ENSMUSP00000139864.2, ENSMUST00000191273.7
    Conserved Domains (3) summary
    smart00213
    Location:2194
    UBQ; Ubiquitin homologues
    smart00264
    Location:133200
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl00155
    Location:1894
    UBQ; Ubiquitin-like proteins
  2. NM_009736.3NP_033866.4  BAG family molecular chaperone regulator 1 isoform 1L

    See identical proteins and their annotated locations for NP_033866.4

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The longer isoform (1L) is represented in this RefSeq.
    Source sequence(s)
    AK009149, AK013611, BQ031093, CX225744
    Consensus CDS
    CCDS38713.1
    UniProtKB/Swiss-Prot
    Q561N1, Q60739, Q6IS45, Q9D7K6
    UniProtKB/TrEMBL
    F6TCF9
    Related
    ENSMUSP00000030125.5, ENSMUST00000030125.5
    Conserved Domains (3) summary
    smart00213
    Location:157230
    UBQ; Ubiquitin homologues
    smart00264
    Location:269336
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl00155
    Location:154230
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40936398..40948294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)