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BAG1 BCL2 associated athanogene 1 [ Homo sapiens (human) ]

Gene ID: 573, updated on 6-Jan-2019

Summary

Official Symbol
BAG1provided by HGNC
Official Full Name
BCL2 associated athanogene 1provided by HGNC
Primary source
HGNC:HGNC:937
See related
Ensembl:ENSG00000107262 MIM:601497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP; BAG-1; RAP46
Summary
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See BAG1 in Genome Data Viewer
Location:
9p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (33252471..33264761, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33252469..33264759, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene B4GALT1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear 15, pseudogene Neighboring gene serine peptidase inhibitor, Kazal type 4 Neighboring gene charged multivesicular body protein 5 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of BAG-1 in Kaposi's sarcoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
adenyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BAG family molecular chaperone regulator 1
Names
BCL2-associated athanogene
Bcl-2 associating athanogene-1 protein
Bcl-2-binding protein
glucocortoid receptor-associated protein RAP46
receptor-associated protein, 46-KD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029018.1 RefSeqGene

    Range
    5001..17291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172415.1NP_001165886.1  BAG family molecular chaperone regulator 1 isoform BAG-1S

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. The most abundant of the shorter isoforms (BAG-1S, also known as p33 or p36), which is derived from the second downstream AUG start codon, is represented in this RefSeq.
    Source sequence(s)
    AL161445, BC001936, BG723775, CN478628
    Consensus CDS
    CCDS55301.1
    UniProtKB/Swiss-Prot
    Q99933
    Related
    ENSP00000369026.2, ENST00000379704.7
    Conserved Domains (3) summary
    smart00213
    Location:41105
    UBQ; Ubiquitin homologues
    smart00264
    Location:131211
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl00155
    Location:29105
    UBQ; Ubiquitin-like proteins
  2. NM_001349286.1NP_001336215.1  BAG family molecular chaperone regulator 1 isoform BAG-1M

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. One of the shorter isoforms (BAG-1M, also known as p46), which is derived from the first downstream AUG start codon, is represented in this RefSeq.
    Source sequence(s)
    AK096038, AL161445, BC001936, BG723775, CN478628
    Conserved Domains (3) summary
    smart00264
    Location:175255
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl00155
    Location:73149
    UBQ; Ubiquitin-like proteins
    cl26511
    Location:267
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_001349299.1NP_001336228.1  BAG family molecular chaperone regulator 1 isoform BAG1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. A minor, shorter isoform (BAG-1, also known as p29), is derived from the third downstream AUG start codon, and is represented in this RefSeq.
    Source sequence(s)
    AK096038, AL161445, BC001936, BG723775, CN478628
    Conserved Domains (2) summary
    smart00264
    Location:108188
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl00155
    Location:682
    UBQ; Ubiquitin-like proteins
  4. NM_004323.6NP_004314.6  BAG family molecular chaperone regulator 1 isoform BAG-1L

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. The longest isoform (BAG-1L) is represented in this RefSeq.
    Source sequence(s)
    AL161445, AL356472
    Consensus CDS
    CCDS35004.1
    Related
    ENSP00000489189.1, ENST00000634734.1
    Conserved Domains (3) summary
    cd01812
    Location:144220
    BAG1_N; Ubiquitin-like domain of BAG1
    smart00264
    Location:246326
    BAG; BAG domains, present in regulator of Hsp70 proteins
    cl26511
    Location:64138
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    33252471..33264761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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