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Atrn attractin [ Mus musculus (house mouse) ]

Gene ID: 11990, updated on 5-Mar-2024

Summary

Official Symbol
Atrnprovided by MGI
Official Full Name
attractinprovided by MGI
Primary source
MGI:MGI:1341628
See related
Ensembl:ENSMUSG00000027312 AllianceGenome:MGI:1341628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mg; Mgca
Summary
This gene encodes a widely expressed transmembrane glycoprotein that plays important roles in diverse physiological processes such as regulation of hair pigmentation, monocyte-T cell interaction and control of energy homeostasis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the mahogany mouse phenotype of dark brown or black coat on a normally agouti background. Mice with loss-of-function mutations in this gene exhibit black coat color, tremor, adiposity, higher basal metabolic rate, juvenile-onset hypomyelination and age-dependent spongiform neurodegeneration of the central nervous system. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in bladder adult (RPKM 35.4), cortex adult (RPKM 13.3) and 27 other tissues See more
Orthologs
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Genomic context

See Atrn in Genome Data Viewer
Location:
2 F1; 2 63.26 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130734363..130872249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130906430..131030333)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 9 Neighboring gene Ppp1r14c pseudogene Neighboring gene RIKEN cDNA A730017L22 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05698 Neighboring gene high mobility group box 1 pseudogene Neighboring gene predicted gene, 30286 Neighboring gene microRNA 6973b Neighboring gene predicted gene, 39937 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pigmentation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
attractin
Names
protein mahogany

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009730.3NP_033860.2  attractin preproprotein

    See identical proteins and their annotated locations for NP_033860.2

    Status: REVIEWED

    Source sequence(s)
    AL833771, AW124828, BE650220, BE953944, BY761276, CB519923, CB520374, CF745736, CN461550
    Consensus CDS
    CCDS16751.1
    UniProtKB/Swiss-Prot
    A2AP43, Q9R263, Q9WU60, Q9WU77
    UniProtKB/TrEMBL
    B9EIU3
    Related
    ENSMUSP00000028781.9, ENSMUST00000028781.9
    Conserved Domains (7) summary
    cd00041
    Location:131246
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:10611106
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:500549
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:339378
    Kelch_1; Kelch motif
    pfam01437
    Location:931982
    PSI; Plexin repeat
    pfam13854
    Location:391427
    Kelch_5; Kelch motif
    cl02432
    Location:787919
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130734363..130872249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498606.5XP_006498669.1  attractin isoform X2

    UniProtKB/TrEMBL
    B9EIU3
    Conserved Domains (7) summary
    smart00423
    Location:683729
    PSI; domain found in Plexins, Semaphorins and Integrins
    PHA03098
    Location:363527
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:168283
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:10981143
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:537586
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:9681019
    PSI; Plexin repeat
    cl02432
    Location:824956
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  2. XM_011239259.2XP_011237561.1  attractin isoform X1

    UniProtKB/TrEMBL
    B9EIU3
    Conserved Domains (7) summary
    smart00423
    Location:533579
    PSI; domain found in Plexins, Semaphorins and Integrins
    PHA03098
    Location:213377
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:25133
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:948993
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:387436
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:818869
    PSI; Plexin repeat
    cl02432
    Location:674806
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain