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Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E [ Mus musculus (house mouse) ]

Gene ID: 11958, updated on 8-Dec-2022

Summary

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Official Symbol
Atp5kprovided by MGI
Official Full Name
ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit Eprovided by MGI
Primary source
MGI:MGI:106636
See related
Ensembl:ENSMUSG00000050856 AllianceGenome:MGI:106636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lfm1; Atp5i; Atp5me; 2610008D24Rik
Summary
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrion. Is expressed in alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 62.8), heart adult (RPKM 59.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Atp5k in Genome Data Viewer
Location:
5 F; 5 53.11 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108581112..108582265, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108433246..108434399, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Neighboring gene predicted gene, 52851 Neighboring gene predicted gene, 34254 Neighboring gene predicted gene, 34319 Neighboring gene solute carrier family 49 member 3 Neighboring gene polycomb group ring finger 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diet-disease interactions at the molecular level: an experimental paradigm. Kaput J, et al. J Nutr, 1994 Aug. PMID 7914920
  2. Testis beta-1,4-galactosyltransferase gene maps to mouse chromosome 5. Kaname T, et al. Genomics, 1998 Oct 1. PMID 9787086
  3. Mouse DNA polymerase epsilon gene (Pole) maps to chromosome 5. Goldsby RE, et al. Mamm Genome, 1998 Jan. PMID 9434959
  4. F1Fo-ATPase subunit e gene isolated in a screen for diet regulated genes. Elliott TS, et al. Biochem Biophys Res Commun, 1993 Jan 15. PMID 7678489
  5. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut. Quaggin SE, et al. J Biol Chem, 1996 Sep 13. PMID 8798433

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107302

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit e, mitochondrial
Names
ATP synthase membrane subunit e
ATPase subunit e
NP_031533.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007507.3 → NP_031533.2  ATP synthase subunit e, mitochondrial

    See identical proteins and their annotated locations for NP_031533.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC158912, BC028438, CO044079
    Consensus CDS
    CCDS39204.1
    UniProtKB/Swiss-Prot
    P70342, Q06185
    UniProtKB/TrEMBL
    A0A8C6HPA8
    Related
    ENSMUSP00000051222.10, ENSMUST00000049628.16
    Conserved Domains (1) summary
    pfam05680
    Location:2 → 35
    ATP-synt_E; ATP synthase E chain

RNA

  1. NR_154996.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The transcript is being represented as non-protein coding since the putative protein would be only 38 aa long.
    Source sequence(s)
    AC158912, AK011342, CO044079
    Related
    ENSMUST00000118632.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108581112..108582265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06185.2 GenPept UniProtKB/Swiss-Prot:Q06185

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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