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ATP5ME ATP synthase membrane subunit e [ Homo sapiens (human) ]

Gene ID: 521, updated on 9-Feb-2020

Summary

Official Symbol
ATP5MEprovided by HGNC
Official Full Name
ATP synthase membrane subunit eprovided by HGNC
Primary source
HGNC:HGNC:846
See related
Ensembl:ENSG00000169020 MIM:601519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5I; ATP5K
Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in colon (RPKM 167.6), kidney (RPKM 153.1) and 25 other tissues See more
Orthologs

Genomic context

See ATP5ME in Genome Data Viewer
Location:
4p16.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (672436..674276, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (666225..668127, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374338 Neighboring gene phosphodiesterase 6B Neighboring gene PDE6B antisense RNA 1 Neighboring gene solute carrier family 49 member 3 Neighboring gene myosin light chain 5 Neighboring gene uncharacterized LOC107986245

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (ATP5I) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12532

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP synthase subunit e, mitochondrial
Names
ATP synthase e chain, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
ATP synthase, H+ transporting, mitochondrial Fo complex subunit E
ATPase subunit e
F1F0-ATP synthase, murine e subunit
NP_009031.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007100.4NP_009031.1  ATP synthase subunit e, mitochondrial

    See identical proteins and their annotated locations for NP_009031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    BC003679, BF215596, BG940181
    Consensus CDS
    CCDS3337.1
    UniProtKB/Swiss-Prot
    P56385
    Related
    ENSP00000306003.4, ENST00000304312.5
    Conserved Domains (1) summary
    pfam05680
    Location:269
    ATP-synt_E; ATP synthase E chain

RNA

  1. NR_033743.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BG940181, DA119852
    Related
    ENST00000505852.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    672436..674276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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