PNLIPRP3 pancreatic lipase related protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PNLIPRP3provided by HGNC
Official Full Name: pancreatic lipase related protein 3provided by HGNC
Primary source: HGNC:HGNC:23492
See related: Ensembl:ENSG00000203837 AllianceGenome:HGNC:23492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, May 2025]
Expression: Biased expression in skin (RPKM 1.9) and esophagus (RPKM 0.8) See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q25.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (116427847..116477957)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (117322181..117372229)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (118187359..118237469)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over expression of pancreatic lipase-related protein 3 is associated with hepatocellular carcinoma.
Title: Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: pancreatic lipase-related protein 3

Names: PL-RP3

NP_001011709.2

EC 3.1.1.3

XP_011537578.1

EC 3.1.1.3

XP_011537579.1

EC 3.1.1.3

XP_011537580.1

EC 3.1.1.3

XP_011537581.1

EC 3.1.1.3

XP_054220729.1

EC 3.1.1.3

XP_054220730.1

EC 3.1.1.3

XP_054220731.1

EC 3.1.1.3

XP_054220732.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011709.3 → NP_001011709.2 pancreatic lipase-related protein 3 precursor

See identical proteins and their annotated locations for NP_001011709.2

Status: VALIDATED

Source sequence(s)

AC011328, BC117224

Consensus CDS

CCDS31292.1

UniProtKB/Swiss-Prot

Q17RR3

Related

ENSP00000358232.3, ENST00000369230.4

Conserved Domains (3) summary

cd00707
Location:52 → 348

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:355 → 467

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:18 → 352

Lipase; Lipase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

116427847..116477957

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011539276.2 → XP_011537578.1 pancreatic lipase-related protein 3 isoform X1

Conserved Domains (2) summary

cd00707
Location:52 → 257

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cl00011
Location:271 → 383

PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
XM_011539279.2 → XP_011537581.1 pancreatic lipase-related protein 3 isoform X3

See identical proteins and their annotated locations for XP_011537581.1

Conserved Domains (2) summary

cd00707
Location:1 → 243

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:250 → 362

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
XM_011539278.1 → XP_011537580.1 pancreatic lipase-related protein 3 isoform X3

See identical proteins and their annotated locations for XP_011537580.1

Conserved Domains (2) summary

cd00707
Location:1 → 243

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:250 → 362

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
XM_011539277.1 → XP_011537579.1 pancreatic lipase-related protein 3 isoform X2

Conserved Domains (2) summary

cd00707
Location:3 → 249

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01759
Location:256 → 368

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...