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PNLIPRP3 pancreatic lipase related protein 3 [ Homo sapiens (human) ]

Gene ID: 119548, updated on 13-May-2022

Summary

Official Symbol
PNLIPRP3provided by HGNC
Official Full Name
pancreatic lipase related protein 3provided by HGNC
Primary source
HGNC:HGNC:23492
See related
Ensembl:ENSG00000203837 AllianceGenome:HGNC:23492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 1.9) and esophagus (RPKM 0.8) See more
Orthologs
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Genomic context

See PNLIPRP3 in Genome Data Viewer
Location:
10q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116427847..116477957)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117322181..117372229)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118187359..118237469)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 172 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 6 Neighboring gene high mobility group box 3 pseudogene 8 Neighboring gene RNA, U6 small nuclear 1090, pseudogene Neighboring gene pancreatic lipase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Homology

General protein information

Preferred Names
pancreatic lipase-related protein 3
Names
PL-RP3
NP_001011709.2
XP_011537578.1
XP_011537579.1
XP_011537580.1
XP_011537581.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011709.3NP_001011709.2  pancreatic lipase-related protein 3 precursor

    See identical proteins and their annotated locations for NP_001011709.2

    Status: VALIDATED

    Source sequence(s)
    AC011328, BC117224
    Consensus CDS
    CCDS31292.1
    UniProtKB/Swiss-Prot
    Q17RR3
    Related
    ENSP00000358232.3, ENST00000369230.4
    Conserved Domains (3) summary
    cd00707
    Location:52348
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:355467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18352
    Lipase; Lipase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116427847..116477957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539276.2XP_011537578.1  pancreatic lipase-related protein 3 isoform X1

    Conserved Domains (2) summary
    cd00707
    Location:52257
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cl00011
    Location:271383
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
  2. XM_011539279.2XP_011537581.1  pancreatic lipase-related protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011537581.1

    Conserved Domains (2) summary
    cd00707
    Location:1243
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:250362
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
  3. XM_011539278.1XP_011537580.1  pancreatic lipase-related protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011537580.1

    Conserved Domains (2) summary
    cd00707
    Location:1243
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:250362
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
  4. XM_011539277.1XP_011537579.1  pancreatic lipase-related protein 3 isoform X2

    Conserved Domains (2) summary
    cd00707
    Location:3249
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:256368
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117322181..117372229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)