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Atf2 activating transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 11909, updated on 27-Aug-2019

Summary

Official Symbol
Atf2provided by MGI
Official Full Name
activating transcription factor 2provided by MGI
Primary source
MGI:MGI:109349
See related
Ensembl:ENSMUSG00000027104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mXBP; Atf-2; Creb2; CRE-BP; D18875; D130078H02Rik; Tg(Gzma-Klra1)7Wum
Expression
Ubiquitous expression in CNS E14 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 28 other tissues See more
Orthologs

Genomic context

See Atf2 in Genome Data Viewer
Location:
2; 2 C3
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73816509..73892677, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73654578..73730685, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), opposite strand Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene predicted gene 10822 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) Neighboring gene predicted gene, 39851

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105211, MGC105222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding protein binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adipose tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
amelogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-2
Names
cAMP response element-binding protein CRE-BP1
cAMP-dependent transcription factor ATF-2
NP_001020264.1
NP_001271298.1
NP_001271299.1
NP_001271300.1
NP_001271301.1
NP_001271302.1
NP_001271303.1
NP_001271305.1
NP_033845.1
XP_030102700.1
XP_030102701.1
XP_030102703.1
XP_030102704.1
XP_030102706.1
XP_030102707.1
XP_030102710.1
XP_030102713.1
XP_030102715.1
XP_030102718.1
XP_030102727.1
XP_030102732.1
XP_030102733.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025093.2NP_001020264.1  cyclic AMP-dependent transcription factor ATF-2 isoform 1

    See identical proteins and their annotated locations for NP_001020264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK051591, AL844581, AL845523, BC079883, BC082596
    Consensus CDS
    CCDS16134.1
    UniProtKB/Swiss-Prot
    P16951
    UniProtKB/TrEMBL
    Q543G2, Q640L6, Q68FE3
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001284369.1NP_001271298.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

    See identical proteins and their annotated locations for NP_001271298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK035438, AK139515, AL844581, AL845523
    Consensus CDS
    CCDS16135.1
    UniProtKB/TrEMBL
    Q543G2, Q8CBR9
    Related
    ENSMUSP00000107641.2, ENSMUST00000112010.8
    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001284370.1NP_001271299.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

    See identical proteins and their annotated locations for NP_001271299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
    Source sequence(s)
    AK035438, AK146839, AL844581, BY474294
    UniProtKB/TrEMBL
    Q8CBR9
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336377
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001284371.1NP_001271300.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

    See identical proteins and their annotated locations for NP_001271300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
    Source sequence(s)
    AK035438, AK146839, AL844581, BY474294
    UniProtKB/TrEMBL
    Q8CBR9
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336377
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001284372.1NP_001271301.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

    See identical proteins and their annotated locations for NP_001271301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523
    Consensus CDS
    CCDS71076.1
    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001284373.1NP_001271302.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

    See identical proteins and their annotated locations for NP_001271302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, BC079883, BC082596
    Consensus CDS
    CCDS71076.1
    UniProtKB/TrEMBL
    Q640L6, Q68FE3
    Related
    ENSMUSP00000107647.2, ENSMUST00000112016.8
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001284374.1NP_001271303.1  cyclic AMP-dependent transcription factor ATF-2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523, BC082596, BC085137
    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (1) summary
    cd14687
    Location:101161
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  8. NM_001284376.1NP_001271305.1  cyclic AMP-dependent transcription factor ATF-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, contains an alternate in-frame exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523, BC079883, BC082596
    UniProtKB/TrEMBL
    Q640L6, Q68FE3
    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:289349
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  9. NM_009715.3NP_033845.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

    See identical proteins and their annotated locations for NP_033845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK051591, AL844581, AL845523, BC079883
    Consensus CDS
    CCDS16135.1
    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Related
    ENSMUSP00000107638.1, ENSMUST00000112007.7
    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    73816509..73892677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246840.1XP_030102700.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    Related
    ENSMUSP00000107648.1, ENSMUST00000112017.7
  2. XM_030246853.1XP_030102713.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

  3. XM_030246846.1XP_030102706.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

    Related
    ENSMUSP00000088311.4, ENSMUST00000090802.10
  4. XM_030246847.1XP_030102707.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

    Related
    ENSMUSP00000133632.1, ENSMUST00000173010.7
  5. XM_030246850.1XP_030102710.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

  6. XM_030246872.1XP_030102732.1  cyclic AMP-dependent transcription factor ATF-2 isoform X5

  7. XM_030246855.1XP_030102715.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

  8. XM_030246858.1XP_030102718.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

  9. XM_030246843.1XP_030102703.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

  10. XM_030246873.1XP_030102733.1  cyclic AMP-dependent transcription factor ATF-2 isoform X6

  11. XM_030246844.1XP_030102704.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

  12. XM_030246841.1XP_030102701.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

  13. XM_030246867.1XP_030102727.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

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