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Atf2 activating transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 11909, updated on 8-Feb-2024

Summary

Official Symbol
Atf2provided by MGI
Official Full Name
activating transcription factor 2provided by MGI
Primary source
MGI:MGI:109349
See related
Ensembl:ENSMUSG00000027104 AllianceGenome:MGI:109349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mXBP; Atf-2; Creb2; CRE-BP; D130078H02Rik; Tg(Gzma-Klra1)7Wum
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; histone acetylation; and intracellular signal transduction. Acts upstream of or within with a positive effect on regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; fat cell differentiation; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atf2 in Genome Data Viewer
Location:
2 C3; 2 43.86 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73646853..73723094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73816509..73892677, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 53265 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene STARR-seq mESC enhancer starr_04840 Neighboring gene STARR-seq mESC enhancer starr_04842 Neighboring gene STARR-seq mESC enhancer starr_04843 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73705882-73706183 Neighboring gene STARR-positive B cell enhancer ABC_E809 Neighboring gene STARR-positive B cell enhancer ABC_E4468 Neighboring gene predicted gene 10822 Neighboring gene ATP synthase membrane subunit c locus 3 Neighboring gene predicted gene, 39851

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105211, MGC105222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP response element binding protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2B acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in abducens nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adipose tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amelogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brainstem development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to anisomycin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to anisomycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect cellular response to leucine starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of cell density IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facial nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth plate cartilage chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth plate cartilage chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hypoglossal nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neurofilament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within_positive_effect regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within white fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in white fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of H4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-2
Names
cAMP response element-binding protein CRE-BP1
cAMP-dependent transcription factor ATF-2
NP_001020264.1
NP_001271298.1
NP_001271299.1
NP_001271300.1
NP_001271301.1
NP_001271302.1
NP_001271303.1
NP_001271305.1
NP_033845.1
XP_030102700.1
XP_030102701.1
XP_030102703.1
XP_030102704.1
XP_030102706.1
XP_030102707.1
XP_030102710.1
XP_030102713.1
XP_030102715.1
XP_030102718.1
XP_030102727.1
XP_030102732.1
XP_030102733.1
XP_036013584.1
XP_036013587.1
XP_036013593.1
XP_036013600.1
XP_036013601.1
XP_036013602.1
XP_036013604.1
XP_036013605.1
XP_036013606.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025093.2NP_001020264.1  cyclic AMP-dependent transcription factor ATF-2 isoform 1

    See identical proteins and their annotated locations for NP_001020264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK051591, AL844581, AL845523, BC079883, BC082596
    Consensus CDS
    CCDS16134.1
    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001284369.1NP_001271298.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

    See identical proteins and their annotated locations for NP_001271298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK035438, AK139515, AL844581, AL845523
    Consensus CDS
    CCDS16135.1
    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Related
    ENSMUSP00000107641.3, ENSMUST00000112010.9
    Conserved Domains (3) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:144272
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001284370.1NP_001271299.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

    See identical proteins and their annotated locations for NP_001271299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
    Source sequence(s)
    AK035438, AK146839, AL844581, BY474294
    UniProtKB/TrEMBL
    G3UXC3, Q8CBR9
    Related
    ENSMUST00000143714.8
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336377
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001284371.1NP_001271300.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

    See identical proteins and their annotated locations for NP_001271300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
    Source sequence(s)
    AK035438, AK146839, AL844581, BY474294
    UniProtKB/TrEMBL
    G3UXC3, Q8CBR9
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336377
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001284372.1NP_001271301.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

    See identical proteins and their annotated locations for NP_001271301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523
    Consensus CDS
    CCDS71076.1
    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001284373.1NP_001271302.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

    See identical proteins and their annotated locations for NP_001271302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, BC079883, BC082596
    Consensus CDS
    CCDS71076.1
    UniProtKB/TrEMBL
    Q640L6
    Related
    ENSMUSP00000107647.3, ENSMUST00000112016.9
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001284374.1NP_001271303.1  cyclic AMP-dependent transcription factor ATF-2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523, BC082596, BC085137
    UniProtKB/TrEMBL
    P70299
    Related
    ENSMUST00000156455.8
    Conserved Domains (1) summary
    cd14687
    Location:101161
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  8. NM_001284376.1NP_001271305.1  cyclic AMP-dependent transcription factor ATF-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, contains an alternate in-frame exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AL844581, AL845523, BC079883, BC082596
    UniProtKB/TrEMBL
    Q68FE3
    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:289349
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  9. NM_009715.3NP_033845.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

    See identical proteins and their annotated locations for NP_033845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK051591, AL844581, AL845523, BC079883
    Consensus CDS
    CCDS16135.1
    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Related
    ENSMUSP00000107638.2, ENSMUST00000112007.8
    Conserved Domains (3) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:144272
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73646853..73723094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246850.2XP_030102710.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

    UniProtKB/TrEMBL
    G3UXC3
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336382
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:72331
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  2. XM_030246847.2XP_030102707.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

    UniProtKB/TrEMBL
    G3UXC3
    Related
    ENSMUSP00000133632.2, ENSMUST00000173010.8
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336382
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05109
    Location:72331
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  3. XM_030246840.2XP_030102700.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Related
    ENSMUSP00000107648.2, ENSMUST00000112017.8
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_030246846.2XP_030102706.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Related
    ENSMUSP00000088311.5, ENSMUST00000090802.11
    Conserved Domains (3) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:144272
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  5. XM_036157694.1XP_036013587.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_030246872.1XP_030102732.1  cyclic AMP-dependent transcription factor ATF-2 isoform X6

    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:198258
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  7. XM_030246855.1XP_030102715.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_030246858.1XP_030102718.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_036157708.1XP_036013601.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Conserved Domains (3) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:144272
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  10. XM_030246843.2XP_030102703.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_030246873.1XP_030102733.1  cyclic AMP-dependent transcription factor ATF-2 isoform X7

    Conserved Domains (2) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238284
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  12. XM_036157711.1XP_036013604.1  cyclic AMP-dependent transcription factor ATF-2 isoform X5

    Conserved Domains (2) summary
    cd12192
    Location:1552
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:206266
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  13. XM_036157707.1XP_036013600.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

    UniProtKB/TrEMBL
    Q543G2, Q68FE3
    Conserved Domains (3) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:144272
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:296356
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  14. XM_036157712.1XP_036013605.1  cyclic AMP-dependent transcription factor ATF-2 isoform X6

    Conserved Domains (2) summary
    cd12192
    Location:944
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:198258
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  15. XM_036157709.1XP_036013602.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. XM_036157691.1XP_036013584.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Related
    ENSMUSP00000097588.5, ENSMUST00000100009.11
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. XM_030246844.2XP_030102704.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  18. XM_030246853.2XP_030102713.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  19. XM_030246841.2XP_030102701.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  20. XM_030246867.1XP_030102727.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    UniProtKB/TrEMBL
    Q640L6
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:238298
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  21. XM_036157700.1XP_036013593.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/Swiss-Prot
    P16951, Q64089, Q64090, Q64091
    UniProtKB/TrEMBL
    Q8CGB4
    Conserved Domains (4) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    PRK14951
    Location:184312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  22. XM_036157713.1XP_036013606.1  cyclic AMP-dependent transcription factor ATF-2 isoform X8

    UniProtKB/TrEMBL
    A2AQF0
    Related
    ENSMUSP00000118560.2, ENSMUST00000128531.8
    Conserved Domains (2) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_004937562.1 RNA Sequence