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Artn artemin [ Mus musculus (house mouse) ]

Gene ID: 11876, updated on 8-Feb-2024

Summary

Official Symbol
Artnprovided by MGI
Official Full Name
arteminprovided by MGI
Primary source
MGI:MGI:1333791
See related
Ensembl:ENSMUSG00000028539 AllianceGenome:MGI:1333791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
neublastin
Summary
This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016]
Expression
Broad expression in testis adult (RPKM 2.2), stomach adult (RPKM 1.6) and 19 other tissues See more
Orthologs
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Genomic context

See Artn in Genome Data Viewer
Location:
4 D1; 4 53.83 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117783105..117787993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117925908..117930795, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene DPH2 homolog Neighboring gene importin 13 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Neighboring gene RIKEN cDNA 9530034E10 gene Neighboring gene predicted gene, 54253

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284191.1NP_001271120.1  artemin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001271120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK015393, AK053914, AL627128
    Consensus CDS
    CCDS18543.1
    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Related
    ENSMUSP00000095526.3, ENSMUST00000097913.9
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  2. NM_001284192.1NP_001271121.1  artemin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK015393, AK053914, AL627128
    UniProtKB/Swiss-Prot
    Q9Z0L2
  3. NM_001284193.1NP_001271122.1  artemin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001271122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK015393, AK053914, AL627128
    Consensus CDS
    CCDS18543.1
    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  4. NM_009711.4NP_033841.1  artemin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK053914, AL627128
    Consensus CDS
    CCDS18543.1
    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Related
    ENSMUSP00000064521.3, ENSMUST00000070816.9
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117783105..117787993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502694.4XP_006502757.1  artemin isoform X2

    See identical proteins and their annotated locations for XP_006502757.1

  2. XM_030253105.1XP_030108965.1  artemin isoform X1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  3. XM_006502693.3XP_006502756.1  artemin isoform X1

    See identical proteins and their annotated locations for XP_006502756.1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  4. XM_006502691.3XP_006502754.1  artemin isoform X1

    See identical proteins and their annotated locations for XP_006502754.1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  5. XM_006502692.3XP_006502755.1  artemin isoform X1

    See identical proteins and their annotated locations for XP_006502755.1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  6. XM_006502690.3XP_006502753.1  artemin isoform X1

    See identical proteins and their annotated locations for XP_006502753.1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
  7. XM_011240419.2XP_011238721.1  artemin isoform X1

    See identical proteins and their annotated locations for XP_011238721.1

    UniProtKB/Swiss-Prot
    Q3SXF4, Q3SXF5, Q9Z0L2
    Conserved Domains (1) summary
    cd19381
    Location:126223
    TGF_beta_Artemin; transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins